Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice.

@article{Badea2007TopicalNG,
  title={Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice.},
  author={Ildiko Badea and Shawn D. Wettig and Ronald E. Verrall and Marianna Foldvari},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={65 3},
  pages={414-22}
}
Cutaneous gene therapy, although a promising approach for many dermatologic diseases, has not progressed to the stage of clinical trials, mainly due to the lack of an effective gene delivery system. The main objective of this study was to construct and evaluate gemini nanoparticles as a topical formulation for the interferon gamma (IFN-gamma) gene in an IFN-gamma-deficient mouse model. Nanoparticles based on the gemini surfactant 16-3-16 (NP16-DNA) and another cationic lipid cholesteryl 3beta… CONTINUE READING

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