Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin 1

@article{Bissett2004TopicalNR,
  title={Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin 1},
  author={Donald Lynn Bissett and Kukizo Miyamoto and Peng Sun and J Li and Cynthia A Berge},
  journal={International Journal of Cosmetic Science},
  year={2004},
  volume={26}
}
Previous clinical testing of topical niacinamide (vitamin B3) has revealed a broad array of improvements in the appearance of aging facial skin. The study reported here was done to confirm some of those previous observations and to evaluate additional end points such as skin anti‐yellowing. Caucasian female subjects (n = 50, aged 40–60 years) participated in a 12‐week, double‐blind, placebo‐controlled, split‐face, left–right randomized clinical study assessing two topical products: moisturizer… 
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Hydroquinone is still the gold standard for the treatment of hyperpigmentation, along with the triple therapy of hydrochinon, tretinoin, and steroids in different modifications, and hyperpIGmentation is best treated using a combination therapy of different approaches that includes consequent UV protection.
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Niacinamide and desonide showed depigmenting properties in women with axillary hyperpigmentation, which may be explained by their antimelanogenic and anti-inflammatory properties, respectively.
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An antiaging skin care system containing AHAs and vitamins significantly improves the biomechanical parameters of the skin including wrinkles and skin texture, as well as elasticity without significant adverse effects.
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Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions that can culminate in PIH and typically most epidermal lesions will appear tan, brown, or dark brown while dermal hyperMelanosis has a blue-gray discoloration.
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An overview of trends in the application of plant extracts as topical treatments for hyperpigmentation disorders is presented, providing in vitro screening results and relevant available clinical study trial findings supporting their efficacy.
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