Topical lidocaine for the treatment of postherpetic neuralgia.

@article{Khaliq2007TopicalLF,
  title={Topical lidocaine for the treatment of postherpetic neuralgia.},
  author={Waqas Khaliq and Serena Alam and Neerja Puri},
  journal={The Cochrane database of systematic reviews},
  year={2007},
  volume={2},
  pages={
          CD004846
        }
}
BACKGROUND The cause of postherpetic neuralgia is damage to peripheral neurons, dorsal root ganglia, and the dorsal horn of the spinal cord, secondary to herpes zoster infection (shingles). In postherpetic neuralgia, peripheral neurons discharge spontaneously and have lowered activation thresholds, and exhibit an exaggerated response to stimuli. Topical lidocaine dampens peripheral nociceptor sensitisation and central nervous system hyperexcitability, and may benefit patients with postherpetic… CONTINUE READING

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