Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.

@article{Frucht1984TopicalIE,
  title={Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.},
  author={Juliane Frucht and Hanan Zauberman},
  journal={The British journal of ophthalmology},
  year={1984},
  volume={68 9},
  pages={
          656-9
        }
}
The effect of indomethacin 1% drops against a placebo (NaCl 0.9% solution) was tested in rabbits' corneas injured by a standardized chemical burn. The corneas treated with indomethacin 1% had less neovascularisation and a much smaller increase in the PGE2 levels as compared with the control fellow eyes treated with a placebo. It appears that indomethacin 1% drops have a clear effect on the inflammatory response of the cornea and deserve a clinical trial in selected patients suffering from… CONTINUE READING

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