Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.

@article{Hung2016TopicalIB,
  title={Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.},
  author={I F N Hung and Anna Jinxia Zhang and Kelvin Kai-Wang To and Jasper Fuk-Woo Chan and Patrick C. K. Li and Tin-Lun Wong and Ricky Zhang and Tuen Ching Chan and Brian Chun-Yuan Chan and Harrison Ho Wai and Lok-Wun Chan and Hugo Pak-Yiu Fong and Raymond Kar-Ching Hui and Ka-Lun Kong and Arthur Chun-Fung Leung and Abe Ho-Ting Ngan and Louise Wing-Ki Tsang and Alex Pat-Chung Yeung and Geo Chi-Ngo Yiu and Wing Ho Yung and Johnson Y-N Lau and Honglin Chen and Kwok-hung Chan and Kwok Yung Yuen},
  journal={The Lancet. Infectious diseases},
  year={2016},
  volume={16 2},
  pages={
          209-18
        }
}
BACKGROUND Pretreatment with topical imiquimod, a synthetic agonist of toll-like receptor 7, significantly improved the immunogenicity of influenza vaccination in elderly people. We aimed to clarify its effect in a younger age group. METHODS In this double-blind, randomised controlled trial, we enrolled healthy volunteers aged 18-30 years in early 2014 to receive the 2013-14 northern-hemisphere winter trivalent influenza vaccine at the Queen Mary Hospital, (Hong Kong, China). Eligible… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2019

Adjuvant strategies to improve vaccination of the elderly population.

  • Current opinion in pharmacology
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND