• DOI:10.1002/BJS.1800830614
Corpus ID: 27460928

Topical glyceryl trinitrate in the treatment of chronic anal fissure

@article{Watson1996TopicalGT,
  title={Topical glyceryl trinitrate in the treatment of chronic anal fissure},
  author={S. J. Watson and M. Kamm and R. J. Nicholls and R. Phillips},
  journal={British Journal of Surgery},
  year={1996},
  volume={83}
}

• S. J. Watson, M. Kamm, +1 author R. Phillips
• Published 1996
• Medicine
• British Journal of Surgery

The aetiology of anal fissure is unclear, but there is an association with high maximum resting pressure (MRP). Internal sphincterotomy reduces MRP and heals fissure through an increase in local blood supply. Glyceryl trinitrate (GTN) is a nitric oxide donor which contributes to internal anal sphincter relaxation via a non‐adrenergic non‐cholinergic pathway. GTN ointment was applied topically in different concentrations to the anal margin in patients with chronic anal fissure to monitor its… Expand

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