Topical glyceryl trinitrate in the treatment of chronic anal fissure

@article{Watson1996TopicalGT,
  title={Topical glyceryl trinitrate in the treatment of chronic anal fissure},
  author={S. J. Watson and M. Kamm and R. Nicholls and R. Phillips},
  journal={British Journal of Surgery},
  year={1996},
  volume={83}
}
The aetiology of anal fissure is unclear, but there is an association with high maximum resting pressure (MRP). Internal sphincterotomy reduces MRP and heals fissure through an increase in local blood supply. Glyceryl trinitrate (GTN) is a nitric oxide donor which contributes to internal anal sphincter relaxation via a non‐adrenergic non‐cholinergic pathway. GTN ointment was applied topically in different concentrations to the anal margin in patients with chronic anal fissure to monitor its… Expand
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References

SHOWING 1-10 OF 22 REFERENCES
Sequelae of internal sphincterotomy for chronic fissure in ano
  • 310
The conservative treatment of fissure‐in‐ano
  • 60
Relationship between anal pressure and anodermal blood flow
  • 298
Long-term results of open and closed sphincterotomy for anal fissure
  • 145
...
1
2
3
...