Topical equol preparation improves structural and molecular skin parameters

  title={Topical equol preparation improves structural and molecular skin parameters},
  author={Ulrich Magnet and Christina Urbanek and Daniela Gaisberger and Elena Tomeva and Elisabeth Dum and Angelika Pointner and Alexander G Haslberger},
  journal={International Journal of Cosmetic Science},
Equol has been shown to improve skin health and regeneration, due to its antioxidative, phytoestrogenic and epigenetic characteristics. The effects of a topical intervention on skin structure, telomere length and epigenetic markers in skin cells were analysed. 
Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin
It is widely accepted that traditional treatments such as local hormone treatment are effective in reversing (estrogen-deficient) aging skin deterioration, but the uncertainly of the effects of long-term systemic menopausal treatment and, more recently, aversion to systemic hormones has led to newer therapeutic agents that can send estrogen's important skin-health signals via selective estrogen receptor modulators (SERMs) other than estrogen itself.
A role for estrogen in skin ageing and dermal biomechanics
Importance and Relevance of Phytochemicals Present in Galenia africana
Many people in developing countries rely primarily on medicinal plants as their main source of healthcare, particularly for the treatment of skin infections. Despite the widespread use of medicinal
4′,7-Isoflavandiol (Equol) Enhances Human Dermal Fibroblast Renewal and Has Effects Similar to 17β-Estradiol in Stimulating Collagen and Elastin Expression. Cell Cycle and RT-PCR Analysis without Phenol Red
The polyphenolic equol compound, derived from plants, may provide protection against photoaging in cosmetic formulations by stimulating collagen, elastin, and enhancing fibroblast renewal.
Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects
Current knowledge on the microorganisms involved in, the genetic background to, and the biochemical pathways of, equol biosynthesis are summarized and the results of recent clinical trials and meta-analyses on the effects of equol on different areas of human health are outlined.
The history and basic science development of soy isoflavones
This review summarizes the 2016 NAMS/Pfizer—Wulf H. Utian Endowed Lecture that focused on the history and basic science of soy isoflavones, and the role of the important intestinally derived metabolite S-(−)equol is described.
Phytoestrogens (Resveratrol and Equol) for Estrogen-Deficient Skin—Controversies/Misinformation versus Anti-Aging In Vitro and Clinical Evidence via Nutraceutical-Cosmetics
  • E. Lephart
  • Biology
    International journal of molecular sciences
  • 2021
The overarching theme for this review is perspective. Superfoods (a marketing term for fruits and vegetables, etc.) have a positive connotation, while many superfoods contain phytoestrogens, a term
A facile access for the synthesis of 1-hetero(aryl)-1,2,3-triazoles linked to equol under mild conditions
The salient features of this developed protocol include: easy isolation process, good to excellent yield of the products and appendage diversity of heteroaryl triazoles.


Photoimmune protective effect of the phytoestrogenic isoflavonoid equol is partially due to its antioxidant activities.
In addition to the activation by equol of oestrogenic signalling pathways for photoprotection, this isoflavonoid also provides UV-protective antioxidant effects that depend partially on HO-1 induction.
Discovering the link between nutrition and skin aging
This review will provide an overview of the current literature “linking” nutrition with skin aging and a variety of plant extracts that have been widely used in the skin care industry either as topically applied agents or oral supplements.
Protective effects of equol and their polyphenolic isomers against dermal aging: Microarray/protein evidence with clinical implications and unique delivery into human skin
These results illustrate the significant differences in mirror-image molecules or isomers of equol where R-Equol and/or racemic equol are better molecules for skin gene expression compared to S-equol and the percutaneous absorption of equl represents a unique epidermal reservoir delivery mechanism.
[Equol: a metabolite of soy isoflavones by intestinal microflora--a review].
The corresponding research results of previous studies have been reviewed, including the underlying mechanism of equol formation and bioavailability, factors influencing equol production and the role of hydrogen gas on microbial Equol formation.
Estrogens and aging skin
The relevance of estrogen replacement, selective estrogen receptor modulators (SERMs) and phytoestrogens as therapies for diminishing skin aging is highlighted and understanding estrogen signaling in skin will provide a basis for interventions in aging pathologies.
Antioxidant efficacy of phytoestrogens in chemical and biological model systems.
The only estrogenic compound with significant antioxidant activity was kaempferol, better known as a dietary antioxidant than a phytoestrogen, which may indicate little significance as antioxidants in vivo.
Present and future of anti-ageing epigenetic diets
Impact of Soy Isoflavones on the Epigenome in Cancer Prevention
The state-of-the-art of IF affecting the epigenome in major hormone-dependent, urogenital, and gastrointestinal tumor types and in in vivo studies on anti-cancer treatment or developmental aspects, and short-term intervention studies in adults suggest that epigenetic gene regulation represents an important novel target of IF and should be taken into consideration when evaluating the cancer preventive potential of IF in humans.
Molecular mechanisms of skin ageing
  • G. Jenkins
  • Biology, Medicine
    Mechanisms of Ageing and Development
  • 2002