Topical equol preparation improves structural and molecular skin parameters

@article{Magnet2017TopicalEP,
  title={Topical equol preparation improves structural and molecular skin parameters},
  author={Ulrich Magnet and Christina Urbanek and Daniela Gaisberger and Elena Tomeva and Elisabeth Dum and Angelika Pointner and Alexander G. Haslberger},
  journal={International Journal of Cosmetic Science},
  year={2017},
  volume={39}
}
Equol has been shown to improve skin health and regeneration, due to its antioxidative, phytoestrogenic and epigenetic characteristics. The effects of a topical intervention on skin structure, telomere length and epigenetic markers in skin cells were analysed. 
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In addition to the activation by equol of oestrogenic signalling pathways for photoprotection, this isoflavonoid also provides UV-protective antioxidant effects that depend partially on HO-1 induction.
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These results illustrate the significant differences in mirror-image molecules or isomers of equol where R-Equol and/or racemic equol are better molecules for skin gene expression compared to S-equol and the percutaneous absorption of equl represents a unique epidermal reservoir delivery mechanism.
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The corresponding research results of previous studies have been reviewed, including the underlying mechanism of equol formation and bioavailability, factors influencing equol production and the role of hydrogen gas on microbial Equol formation.
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