Topical efficacy of dimercapto-chelating agents against lewisite-induced skin lesions in SKH-1 hairless mice.

@article{Mouret2013TopicalEO,
  title={Topical efficacy of dimercapto-chelating agents against lewisite-induced skin lesions in SKH-1 hairless mice.},
  author={St{\'e}phane Mouret and Julien Wartelle and Sandy Emorine and Marine Bertoni and Nina Nguon and C{\'e}cile Cl{\'e}ry-Barraud and Fr{\'e}d{\'e}ric Dorandeu and Isabelle Boudry},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={272 2},
  pages={291-8}
}
Lewisite is a potent chemical warfare arsenical vesicant that can cause severe skin lesions. Today, lewisite exposure remains possible during demilitarization of old ammunitions and as a result of deliberate use. Although its cutaneous toxicity is not fully elucidated, a specific antidote exists, the British anti-lewisite (BAL, dimercaprol) but it is not without untoward effects. Analogs of BAL, less toxic, have been developed such as meso-2,3-dimercaptosuccinic acid (DMSA) and have been… CONTINUE READING
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