Topical dose justification: benzoyl peroxide concentrations

@article{Brandstetter2013TopicalDJ,
  title={Topical dose justification: benzoyl peroxide concentrations},
  author={A. Brandstetter and Howard I Maibach},
  journal={Journal of Dermatological Treatment},
  year={2013},
  volume={24},
  pages={275 - 277}
}
Abstract Background: Benzoyl peroxide (BPO) is widely utilized in acne treatment as an alternative to antibiotics against which Propionibacterium acnes becomes more resistant. Objective: This overview examines BPO dose justification. Methods: PubMed, Embase® and Science Citation Index searches were conducted using the keywords “benzoyl peroxide” and “acne vulgaris”. Results: Limited experimental data are available. However, there appears no significant difference in the efficacy of… 

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References

SHOWING 1-10 OF 20 REFERENCES

[Open, controlled multicenter trial of 2 benzoyl peroxide preparations in the treatment of acne vulgaris].

  • H. Wokalek
  • Medicine
    Zeitschrift fur Hautkrankheiten
  • 1989
In an open multicenter study, 109 patients with acne vulgaris were treated with Cordes Benzoyl Peroxide (BPO) 3%, 5%, and 10%, or a reference preparation. With few exceptions, both preparations

Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris

The 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules).

BENZOYL PEROXIDE GEL THERAPY IN ACNE IN SINGAPORE

  • C. C. Yong
  • Medicine
    International journal of dermatology
  • 1979
It is shown that benzoyl peroxide, in a stable gel formulation, both in 2.5% and 5% strengths, was highly efficacious in the topical treatment of acne vulgaris without con‐comitant systemic therapy.

[Clinico-experimental studies on the effect of benzoylperoxide].

  • M. Puschmann
  • Medicine, Biology
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 1982
Alcohol-free gels of benzoyl peroxide are better tolerated by acne patients than those containing alcohol, in particular when combined with topical tretinoin (vitamin A acid) treatment.

Benzoyl peroxide: percutaneous penetration and metabolic disposition. II. Effect of concentration.

Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule.

  • Medicine, Chemistry
    Federal register
  • 2010
A final rule to include benzoyl peroxide as a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter (OTC) topical acne drug products is issued.

Polymorphic Cytochrome P450 Enzymes and Post-Marketing Drug Dosage Revisions: Clinical Relevance to Dermatologic Therapies

The biochemistry of CYP enzymes and the clinical implications of genetic polymorphisms as relating to certain dermatologic drugs are reviewed and the potential clinical function of cutaneous CYP enzyme is discussed.

Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition

In vitro percutaneous absorption of model compounds glyphosate and malathion and a model permeation of N-nitrosamines through human skin nail penetration focus on topical delivery of antifungal drugs for onchomycosistreatment topical dermatological vehicles - a holistic approach.

OF HEALTH AND HUMAN SERVICES Food and Drug Administration

Evaluated results and behaviors and sexual activities will be used to examine experiences of participants in the RCT.