Topical dose justification: benzoyl peroxide concentrations

  title={Topical dose justification: benzoyl peroxide concentrations},
  author={A. Brandstetter and Howard I Maibach},
  journal={Journal of Dermatological Treatment},
  pages={275 - 277}
Abstract Background: Benzoyl peroxide (BPO) is widely utilized in acne treatment as an alternative to antibiotics against which Propionibacterium acnes becomes more resistant. Objective: This overview examines BPO dose justification. Methods: PubMed, Embase® and Science Citation Index searches were conducted using the keywords “benzoyl peroxide” and “acne vulgaris”. Results: Limited experimental data are available. However, there appears no significant difference in the efficacy of… 

Newer Approaches to the Treatment of Acne Vulgaris

  • T. Simonart
  • Medicine
    American Journal of Clinical Dermatology
  • 2012
The purpose of this paper is to discuss the therapies available for acne and their latest developments, including new treatment strategies, and their rationale and likely place in treatment.

Acne Vulgaris

Acne VulgarisThe negative psychological effect of acne vulgaris can be profound and long‐lasting.Combination therapy with a retinoid and a benzoyl peroxide–containing antimicrobial agent is used to

Topical Treatments in Reducing Propionibacterium Acnes Infection in Shoulder Surgery: Protocol for a Systematic Review and Meta-analysis

This systematic review and meta-analysis evaluates the effectiveness of topical preparations in reducing the prevalence of P acnes in shoulder surgery and determines the primary outcome is the number of colony forming units.

Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017

The Guidelines for the Treatment of Acne Vulgaris of the Japanese Dermatological Association was first published in Japanese in 2008 and revised in 2016 and 2017, which more strongly recommend combination therapies, especially fixed‐dose combination gels including BPO in the aspects of pharmacological actions and compliance in the acute inflammatory phase.

Consenso en el tratamiento tópico del acné Consensus in the topical treatment of acne

Molecules, indications, dosage and side effects are analyzed from the point of view of scientific evidence, making a multidisciplinary consensus among dermatologists, pediatricians and general practitioners on the topical acne treatment.

What's new in acne? An analysis of systematic reviews published in 2011–2012

This review summarizes important clinical developments in acne vulgaris identified from 17 systematic reviews published between February 2011 and August 2012, finding good evidence that acne negatively affects quality of life, self‐esteem and mood in adolescents and that combined oral contraceptives are of benefit in both inflammatory and non‐inflammatory acne.

A review on analytical method development, optimization and validation of combination of Azithromycin and benzoyl peroxide by RP-HPLC using design of experiment as per ICH guideline

The aim of this work was to develop modern, rapid, precise and reproducible, but also cost-effective HPLC assay methods which are generally available and applicable for most users.

Consenso en el tratamiento tópico del acné

Las moleculas, indicaciones, posologia and efectos secundarios se analizan desde el punto of vista oficial de la evidencia cientifica, logrando un consenso multidisciplinario entre dermatologos, pediatras and medicos de atencion primaria en el tratamiento topico del acne.



[Open, controlled multicenter trial of 2 benzoyl peroxide preparations in the treatment of acne vulgaris].

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In an open multicenter study, 109 patients with acne vulgaris were treated with Cordes Benzoyl Peroxide (BPO) 3%, 5%, and 10%, or a reference preparation. With few exceptions, both preparations

Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris

The 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules).


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It is shown that benzoyl peroxide, in a stable gel formulation, both in 2.5% and 5% strengths, was highly efficacious in the topical treatment of acne vulgaris without con‐comitant systemic therapy.

[Clinico-experimental studies on the effect of benzoylperoxide].

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    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
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Alcohol-free gels of benzoyl peroxide are better tolerated by acne patients than those containing alcohol, in particular when combined with topical tretinoin (vitamin A acid) treatment.

Benzoyl peroxide: percutaneous penetration and metabolic disposition. II. Effect of concentration.

Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule.

  • Medicine, Chemistry
    Federal register
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A final rule to include benzoyl peroxide as a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter (OTC) topical acne drug products is issued.

Polymorphic Cytochrome P450 Enzymes and Post-Marketing Drug Dosage Revisions: Clinical Relevance to Dermatologic Therapies

The biochemistry of CYP enzymes and the clinical implications of genetic polymorphisms as relating to certain dermatologic drugs are reviewed and the potential clinical function of cutaneous CYP enzyme is discussed.

Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition

In vitro percutaneous absorption of model compounds glyphosate and malathion and a model permeation of N-nitrosamines through human skin nail penetration focus on topical delivery of antifungal drugs for onchomycosistreatment topical dermatological vehicles - a holistic approach.

OF HEALTH AND HUMAN SERVICES Food and Drug Administration

Evaluated results and behaviors and sexual activities will be used to examine experiences of participants in the RCT.