Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study.

@article{Bertelli1995TopicalDF,
  title={Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study.},
  author={Gianfilippo Bertelli and Alberto Gozza and G. B. Forno and M G Vidili and Stefania Silvestro and Marco Venturini and Lucia Del Mastro and Ornella Garrone and Ricardo Rosso and Daniele Dini},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1995},
  volume={13 11},
  pages={2851-5}
}
PURPOSE To evaluate the activity and tolerability of dimethylsulfoxide (DMSO) in the prevention of soft tissue toxicity after extravasation of cytotoxic drugs. PATIENTS AND METHODS From June 1991 to December 1994, all patients who had an extravasation during intravenous (IV) infusion of cytotoxic drugs in our institution were considered for an open, prospective study of preventive treatment with 99% DMSO, applied topically on the extravasation site every 8 hours for 7 days. Intermittent local… CONTINUE READING
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