Topical calcitriol protects from UV-induced genetic damage but suppresses cutaneous immunity in humans.

@article{Damian2010TopicalCP,
  title={Topical calcitriol protects from UV-induced genetic damage but suppresses cutaneous immunity in humans.},
  author={Diona L. Damian and Young Jin Kim and Katie Marie Dixon and Gary M Halliday and Arash Javeri and R S Mason},
  journal={Experimental dermatology},
  year={2010},
  volume={19 8},
  pages={e23-30}
}
Calcitriol, the biologically active form of vitamin D, has been reported to cause both suppressive and protective immune effects in mice. Its immune effects in vivo in humans are unclear. We investigated the in vivo effects of topical calcitriol on minimal erythema dose and skin immune responses in healthy volunteers. We found that calcitriol did not protect from ultraviolet (UV)-induced erythema (sunburn) when applied either 24 h before or immediately after irradiation, although it decreased… CONTINUE READING