Topical calcipotriol plus oral fumaric acid is more effective and faster acting than oral fumaric acid monotherapy in the treatment of severe chronic plaque psoriasis vulgaris.

@article{Gollnick2002TopicalCP,
  title={Topical calcipotriol plus oral fumaric acid is more effective and faster acting than oral fumaric acid monotherapy in the treatment of severe chronic plaque psoriasis vulgaris.},
  author={Harald P. M. Gollnick and Peter Altmeyer and Roland Kaufmann and Johannes Hofaker Ring and Enno Christophers and Stan Pavel and John Ziegler},
  journal={Dermatology},
  year={2002},
  volume={205 1},
  pages={46-53}
}
BACKGROUND Calcipotriol is an established topical therapy for psoriasis vulgaris. OBJECTIVE This study aimed to investigate whether the addition of calcipotriol to fumaric acid ester (FAE) monotherapy had an additive efficacy and an FAE-sparing effect in patients with severe plaque psoriasis. METHODS This multicentre, randomised, double-blind, vehicle-controlled study included 143 patients for up to 13 weeks treatment. Group A received FAE tablets (Fumaderm) with an increasing daily dosage… CONTINUE READING