Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity.

@article{Ciprandi1996TopicalAR,
  title={Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity.},
  author={Giorgio Ciprandi and Chiara Daniela Pronzato and Giovanni Passalacqua and Vittorio Ricca and J Gr{\"o}gen and Giuseppi Sandro Mela and Paola Varese and Carlo Bertolini and Marcello Bagnasco and Giorgio Walter Canonica},
  journal={The Journal of allergy and clinical immunology},
  year={1996},
  volume={98 6 Pt 1},
  pages={1088-96}
}
BACKGROUND It is well known that allergen-specific nasal challenge (ASNC) is a fruitful tool with which to evaluate antiallergic activity exerted by a drug. Azelastine is a new antihistamine also available in topical form (i.e., nasal spray). OBJECTIVE The aim of the study was to evaluate the effects of azelastine nasal spray on inflammatory changes after ASNC in both the early-phase reaction and the late-phase reaction. METHODS The study had a double-blind, placebo-controlled, randomized… CONTINUE READING