Topical application of tranexamic acid for the reduction of bleeding.

  title={Topical application of tranexamic acid for the reduction of bleeding.},
  author={Katharine Ker and Deirdre Beecher and Ian Roberts},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Intravenous tranexamic acid reduces bleeding in surgery, however, its effect on the risk of thromboembolic events is uncertain and an increased risk remains a theoretical concern. Because there is less systemic absorption following topical administration, the direct application of tranexamic acid to the bleeding surface has the potential to reduce bleeding with minimal systemic effects. OBJECTIVES To assess the effects of the topical administration of tranexamic acid in the control… CONTINUE READING


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