Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival.

@article{Bock2013TopicalAO,
  title={Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival.},
  author={Felix Bock and Susanne Roessner and Jasmine Onderka and Matthias Lechmann and Maria Teresa Pallotta and Francesca Fallarino and Louis Boon and Charles A Nicolette and Mark A Debenedette and Irina Y. Tcherepanova and Ursula Grohmann and Alexander Steinkasserer and Claus Cursiefen and Elisabeth Zinser},
  journal={Journal of immunology},
  year={2013},
  volume={191 4},
  pages={1965-75}
}
Modulation of immune responses is one of the main research aims in transplant immunology. In this study, we investigate the local immunomodulatory properties of soluble CD83 (sCD83) at the graft-host interface using the high-risk corneal transplantation model. In this model, which mimics the inflammatory status and the preexisting vascularization of high-risk patients undergoing corneal transplantation, allogeneic donor corneas are transplanted onto sCD83-treated recipient animals. This model… CONTINUE READING
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