Topical application of povidone‐iodine before wound closure is associated with significant increase in serum iodine level

@article{Wong2011TopicalAO,
  title={Topical application of povidone‐iodine before wound closure is associated with significant increase in serum iodine level},
  author={Randolph H L Wong and Vivien Wong and Emily C. W. Hung and Ping-yin. Lee and Calvin S H Ng and Innes Y. P. Wan and Malcolm John Underwood},
  journal={Surgical Practice},
  year={2011},
  volume={15}
}
Aim:  To determine serum iodine level before and after local application of povidone‐iodine before wound closure in cardiac surgery patients. Povidone‐iodine is a popular antiseptic solution that has been widely used in perioperative wound management of surgical patients. Despite its widespread usage, little is known concerning the absorption profile and potential systemic toxicity. 

Iodine pleurodesis--a word of caution.

  • R. WongC. NgM. Underwood
  • Medicine, Biology
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
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It is suggested that a single application of povidone–iodine to subcutaneous tissue can cause a significant increase in post-operative serum iodine levels and possible altered mental status in susceptible individuals, and proposed that patients with malignant pleural effusion might have impaired pleural absorption and hence lower the chance of systemic iodine toxicity.

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This study intended to investigate the alternative therapies described for the adjuvant treatment of vulvovaginitis caused by Candida species, including alternative and complementary treatment methods used by women, using the Brazilian Government's Capes Periodicals Portal and Google Scholar and SciELO databases.

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The results indicate that caution should be used when povidone-iodine is placed on an open wound, and that prolonged contact with viable uncontaminated tissue should be avoided.