Topical application of povidone‐iodine before wound closure is associated with significant increase in serum iodine level

  title={Topical application of povidone‐iodine before wound closure is associated with significant increase in serum iodine level},
  author={Randolph H L Wong and Vivien Wong and Emily C. W. Hung and Ping-yin. Lee and Calvin S H Ng and Innes Y. P. Wan and Malcolm John Underwood},
  journal={Surgical Practice},
Aim:  To determine serum iodine level before and after local application of povidone‐iodine before wound closure in cardiac surgery patients. Povidone‐iodine is a popular antiseptic solution that has been widely used in perioperative wound management of surgical patients. Despite its widespread usage, little is known concerning the absorption profile and potential systemic toxicity. 

Iodine pleurodesis--a word of caution.

  • R. WongC. NgM. Underwood
  • Medicine, Biology
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2012
It is suggested that a single application of povidone–iodine to subcutaneous tissue can cause a significant increase in post-operative serum iodine levels and possible altered mental status in susceptible individuals, and proposed that patients with malignant pleural effusion might have impaired pleural absorption and hence lower the chance of systemic iodine toxicity.

A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds.

SHRO was well tolerated and shows great promise as an effective potent topical antimicrobial in the healing of challenging wounds.

Engineered honey: In vitro antimicrobial activity of a novel topical wound care treatment.

Alternative and complementary therapies for vulvovaginal candidiasis

This study intended to investigate the alternative therapies described for the adjuvant treatment of vulvovaginitis caused by Candida species, including alternative and complementary treatment methods used by women, using the Brazilian Government's Capes Periodicals Portal and Google Scholar and SciELO databases.



Povidone‐iodine wound irrigation: A word of caution

A dialysis‐dependent renal failure patient is reported with clinical manifestation of systemic iodine toxicity after irrigation of an infected mediastinal wound with povidone‐iodine solution.

Povidone-iodine irrigation of the subcutaneous tissue to prevent surgical wound infections.

No beneficial effect of irrigation with povidone-iodine solution could be demonstrated, nor could it be demonstrated in the group as a whole or in the subgroups according to bacterial contamination.

Irrigation of subcutaneous tissue with povidone-iodine solution for prevention of surgical wound infections.

Five hundred patients undergoing a variety of general surgical operative procedures were prospectively randomly allocated into a treatment group, in which the incisions were irrigated with

Iodine toxicity in a patient treated by continuous povidone-iodine mediastinal irrigation.

Povidone‐Iodine–Induced Burn: Case Report and Review of the Literature

Clinicians need to be aware of this possible povidone‐iodine–associated adverse drug reaction, and of preventive measures, given the widespread use of povids and the potential for development of infection after a burn.


Dilute Povidone‐Iodine Solutions Inhibit Human Skin Fibroblast Growth

  • A. BalinL. Pratt
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2002
The results indicate that caution should be used when povidone-iodine is placed on an open wound, and that prolonged contact with viable uncontaminated tissue should be avoided.