Topical application of hPDGF-A-modified porcine BMSC and keratinocytes loaded on acellular HAM promotes the healing of combined radiation-wound skin injury in minipigs.

@article{Yan2011TopicalAO,
  title={Topical application of hPDGF-A-modified porcine BMSC and keratinocytes loaded on acellular HAM promotes the healing of combined radiation-wound skin injury in minipigs.},
  author={Guohe Yan and HuiQin Sun and Feng Wang and Junping Wang and Fengchao Wang and Zhongmin Zou and Tianmin Cheng and Guoping Ai and Yongping Su},
  journal={International journal of radiation biology},
  year={2011},
  volume={87 6},
  pages={591-600}
}
PURPOSE To evaluate the efficacy of cultured cutaneous substitute (CCS) in accelerating the healing of combined radiation-skin wound injury (CRWI) in minipigs. MATERIAL AND METHODS Autologous porcine bone marrow-derived mesenchymal stem cells (BMSC) and skin-derived keratinocytes (SK) were infected by recombinant retrovirus expressing human (h) platelet-derived growth factor-A (hPDGF-A). CCS was constructed by loading acellular human amniotic membrane (HAM) with normal porcine BMSC and SK… CONTINUE READING
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