Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats.

@article{Kudo2011TopicalAO,
  title={Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats.},
  author={Tomohiro Kudo and Shinichi Okamura and Yajing Zhang and Takashige Masuo and Masatomo Mori},
  journal={World journal of gastroenterology},
  year={2011},
  volume={17 17},
  pages={2223-8}
}
AIM To examine the efficacy of glycyrrhizin preparation (GL-p) in the treatment of a rat model of ulcerative colitis (UC). METHODS Experimental colitis was induced by oral administration of dextran sodium sulfate. Rats with colitis were intrarectally administered GL-p or saline. The extent of colitis was evaluated based on body weight gain, colon wet weight, and macroscopic damage score. The expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by… CONTINUE READING
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