Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion.

@article{Fujiyama2016TopicalAO,
  title={Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion.},
  author={Toshiharu Fujiyama and Taisuke Ito and Takatsune Umayahara and Shigeki Ikeya and Kazuki Tatsuno and Atsuko Funakoshi and Hideo Hashizume and Yoshiki Tokura},
  journal={The Journal of allergy and clinical immunology},
  year={2016},
  volume={138 2},
  pages={
          517-528.e5
        }
}
BACKGROUND Topical combination of a vitamin D3 analogue and corticosteroid is widely used for the treatment of psoriasis, a TH17-mediated disorder, but the underlying mechanism remains unclear. OBJECTIVE We investigated the effect of this topical applicant, focusing on skin-infiltrating TH17 cells. METHODS In 10 patients with plaque psoriasis, calcipotriol (Cal), betamethasone dipropionate (Bet), or the calcipotriol and betamethasone dipropionate 2-compound formulation (CB) was applied to 3… CONTINUE READING
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