Topical application of Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces cell cycle arrest in the rat gingival epithelium in vivo.

@article{Ohara2011TopicalAO,
  title={Topical application of Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces cell cycle arrest in the rat gingival epithelium in vivo.},
  author={Masaru Ohara and Mutsumi Miyauchi and Kazuto Tsuruda and Takashi Takata and Motoyuki Sugai},
  journal={Journal of periodontal research},
  year={2011},
  volume={46 3},
  pages={389-95}
}
BACKGROUND Aggregatibacter actinomycetemcomitans is one of the etiological pathogens implicated in the onset of periodontal disease. This pathogen produces cytolethal distending toxin (CDT) that acts as a genotoxin to induce cell cycle arrest and cellular distension in cultured cell lines. Therefore, CDT is a possible virulence factor; however, the in vivo activity of CDT on periodontal tissue has not been explored. Here, CDT was topically applied into the rat molar gingival sulcus; and the… CONTINUE READING
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