Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial.

@article{Weschta2004TopicalAT,
  title={Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial.},
  author={Michael Weschta and Dagmar Rimek and Marc Formanek and Doreen Polzehl and Andreas Podbielski and Herbert Riechelmann},
  journal={The Journal of allergy and clinical immunology},
  year={2004},
  volume={113 6},
  pages={1122-8}
}
BACKGROUND Recently, fungal elements were suspected to be the causative agent of chronic rhinosinusitis, and benefits of topical amphotericin B therapy have been reported. OBJECTIVE The effects of amphotericin B versus control nasal spray on chronic rhinosinusitis were compared in a double-blind, randomized clinical trial. METHODS Patients with chronic rhinosinusitis were administered 200 microL per nostril amphotericin B (3 mg/mL) or saline nasal spray 4 times daily over a period of 8… CONTINUE READING

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