Topical antibody delivery systems produce sustained levels in mucosal tissue and blood

@article{Kuo1998TopicalAD,
  title={Topical antibody delivery systems produce sustained levels in mucosal tissue and blood},
  author={Patricia Y. Kuo and Jill K. Sherwood and W. Mark Saltzman},
  journal={Nature Biotechnology},
  year={1998},
  volume={16},
  pages={163-167}
}
Immunity at mucosal surfaces, which are ports of entry for many pathogens, is essential in preventing infections. But most current strategies for passive immunization involve injection of antibodies for systemic, not mucosal, protection. We measured mucosal and systemic antibody levels after controlled topical delivery to the vagina. Poly(ethylene-co-vinyl acetate) disks containing 125l-labeled monoclonal IgG or anti-lactate dehydrogenase-C4 antibodies were placed in the vaginas of mice. High… CONTINUE READING