• Corpus ID: 44202560

Topical antibiotics in dermatology: An update

  title={Topical antibiotics in dermatology: An update},
  author={Robert A. Schwartz and Nawaf Al‐Mutairi},
The skin presents a first line of defense against a wide range of bacterial invaders. When the integrity of the skin is compromised accidentally or intentionally, its natural defenses weaken and a role for antibacterials emerges. The topical route offers several advantages, including the avoidance of systemic toxicity and side effects, the decreased induction of bacterial resistance, and the high concentration of antibacterial agent at the site of infection. Resistance to topical antibiotics is… 

Topical Antibacterials and Global Challenges on Resistance Development

For skin bacterial infection, topical route of administration is preferred over systemic administration due to the delivery of a higher concentration of medication for the former into the desired area, which is less likely to cause systemic side effects, toxicity, and bacterial resistance.

Evaluation of Acute and Sub-Chronic Toxicities and the Effect of Ointment Bases on the Antimicrobial Potency of the Ethanolic Extracts of Alchornea cordifolia Leaf and Terminalia superba Stem Bark

Interest in research for newer antimicrobial compounds of natural origin and likely to be less toxic to man has triggered renewed interest in the use of medicinal plants as sources of effective and safer alternatives in the management of human infections.

Topical antibiotics in pregnancy: A review of safety profiles

Human studies, animal studies, and pharmacokinetics data are aggregated to provide recommendations on utilizing topical antibiotics in pregnancy.


Cream and ointment of 3% ethanolic extract of Kaempferia pandurata rhizomes had in situ antibacterial activity against skin infection caused by S. aureus in rabbits and did not irritate the skin and eyes of rabbits.

Erythrasma of Palm: Presentation at the Rare Site

The disappearance of pigmented patches following a course of erythromycin and the absence of coral red fluorescence on Wood’s lamp examination post‐treatment substantiate the diagnosis of eriesma, a 28‐year‐old lady presented with asymptomatic brown patch on the left palm of 1‐week duration.


It can be concluded that the follicular route is an important route for the drug delivery through the skin for both topical and systemic drug delivery.


The present review is a trial to focus on various Indian ethno-medicinal plants which are to be scientifically proved for the treatment of wounds to shorten the time required for healing process or to reduce the undue effects.


The present review is an attempt to highlight various Indian ethno-medicinal plants which are to be scientifically proved for the treatment of wounds with emphasis on normal wound healing process, pharmacological activities and role of plants in wound management and parameters used to assess wound healing.

Prescription Patterns of Antibiotics in Five Dermatologic Outpatient Clinics: A Cross Sectional Study from Yemen

Most cases had eczema and dermatitis, Macrolides were most commonly prescribed and one week duration prescribed for most cases, and most cases improved clinically with the use of antibiotics that followed established therapeutic guidelines.

Prescription audit of Corticosteroids in Dermatology OPD of a tertiary care teaching hospital of tribal region of central-south India.

Use of Corticosteroids were not the top in list but adequate information was not written in some of the records with regard to the site of application, duration and quantity of the corticosteroid to be dispensed, suggesting that use of the drugs mostlyby generic name is a welcome initiative towards the rationality.



Local antibiotics in dermatology

Retapamulin, a novel topical antibacterial agent, will probably replace the use of the old mupirocin and fusidic acid in the management of acne and atopic dermatitis.

Topical Antibacterial Agents for Wound Care: A Primer

&NA; Although often overlooked, topical antibiotic agents play an important role in dermatology. Their many uses include prophylaxis against cutaneous infections, treatment of minor wounds and

Topical antibiotics in dermatology.

Topical antibiotics are safe and effective in certain conditions, but extensive use, especially in closed populations, may encourage the emergence of resistant bacteria.

Antimicrobial therapy for skin infections.

Patients with venous ulcers and atopic eczema do not benefit from systemic antimicrobial therapy unless obvious infection is present, as indicated by clinical features such as fever, cellulitis, and lymphangitis.

Rationale for topical antibiotics.

It is concluded that topical antibiotics have a place in the prevention and treatment of superficial skin infections and were shown to be highly effective in preventing and suppressing experimental S. aureus infections in human volunteers.

Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771

Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections in Japan but has potential as a topical agent for short-term treatment of skin infections.

Tackling the anterior nares and other sites of colonization: implications for the dermatologist.

Although decolonization would seem to be a logical means to reduce the incidence of infection, the data supporting eradication of S aureus nasal colonization as a prophylactic are equivocal.

Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistance.

Retinoids are important components in combination therapy for acne, including use with antibiotics, and can serve as an alternative to these agents in maintenance therapy, by increasing the understanding of the multifaceted actions of antibiotics and the known clinical implications of antibiotic resistance.

[Cutaneous Staphylococcus aureus colonisation of atopic eczema. Mechanisms, pathophysiological importance and therapeutic consequences].

  • D. AbeckM. Mempel
  • Biology, Medicine
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 1998
Mechanisms for the increased Staphylococcus aureus colonization in atopic eczema are only partially known but the presence of various extracellular matrix components seems important and in the host epidermal lipid deficencies disturbing barrier dysfunction are important.