Topical antibiotic treatment for uncomplicated skin and skin structure infections: review of the literature

@article{Pangilinan2009TopicalAT,
  title={Topical antibiotic treatment for uncomplicated skin and skin structure infections: review of the literature},
  author={Ronald Pangilinan and Alan D. Tice and Glenn Tillotson},
  journal={Expert Review of Anti-infective Therapy},
  year={2009},
  volume={7},
  pages={957 - 965}
}
Uncomplicated skin infections account for almost 200 million physician-office visits in the USA annually. Treating these infections is estimated to cost in excess of US$350 million each year. The primary etiology of these infections is Staphylococcus aureus, over 60% of which is estimated to be methicillin resistant across the USA. Therapeutic options include incision and drainage in combination with antimicrobial therapy, which may be oral, topical or occasionally parenteral. Because the… Expand
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The findings of a recently published randomized, double-blind, placebo-controlled trial are evaluated to determine whether ‘standard-of-care’ antimicrobial therapy is needed after adequate surgical incision and drainage of uncomplicated skin and soft-tissue abscesses. Expand
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Clinical response to mupirocin ointment was significantly better than that seen with erythromycin and similar to that with flucloxacillin and post-treatment samples from 76 patients showed that in the m upirocin group all the pathogens originally isolated were eliminated, including Gram-negative organisms. Expand
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TLDR
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Mupirocin cream applied topically 3 times daily is as effective as oral cephalexin given 4 times daily for the treatment of secondarily infected wounds and was well tolerated. Expand
Mupirocin cream is as effective as oral cephalexin in the treatment of secondarily infected wounds.
TLDR
Mupirocin cream applied topically 3 times daily is as effective as oral cephalexin given 4 times daily for the treatment of secondarily infected wounds and was well tolerated. Expand
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