Topical anti‐itch therapy

  title={Topical anti‐itch therapy},
  author={Jana Hercogov{\'a}},
  journal={Dermatologic Therapy},
ABSTRACT:  Topical anti‐itch therapy could be causative (antiviral, antimycotic, and/or antiparasitic preparations) or symptomatic. Symptomatic therapy includes substituting some other sensation by cooling, heating, and/or counterirritation, by anesthesia of sensory nerve endings with local anesthetics, blocking mediators of pruritus (to deplete substance P or to block acetylcholine release), and reducing inflammation of the skin with corticosteroids or topical immunomodulators (pimecrolimus… 
Management and treatment of pruritus.
Treatment may include prescription and over-the-counter medications, herbal remedies, hydrotherapy, phototherapy, and ultraviolet therapy, which aims at eliminating the underlying cause first, followed by the management of the itchy sensation.
Pharmacological interventions for generalised itching (not caused by systemic disease or skin lesions) in pregnancy.
There is no evidence from randomised controlled trials to guide practice in terms of the effectiveness and safety of pharmacological interventions for treating generalised itching in pregnancy, and well-designed randomisedcontrolled trials are needed in order to evaluate the effectiveness.
Nonsteroidal, nonimmunosuppressive therapies for pruritus.
  • P. Bloom
  • Medicine
    The Veterinary clinics of North America. Small animal practice
  • 2013
Comparative Study of Unna's Boot and Betamethasone Cream in the Treatment of Sulfur Mustard–Related Pruritus
Unna's Boot seems to be a better choice in controlling sulfur mustard–related pruritus compared with betamethason, and definite side effects of local long-term therapy with corticosteroids and nearly equal efficacy of UnNA's Boot and Betamethasone are nearly equal.
Postburn pruritus: A practical review
Current evidence supports the use of gabapentin/pregabalin in patients with moderate to severe postburn pruritus as the first line, even if as an "off label" indication.
Interventions for chronic pruritus of unknown origin.
This study investigated the safety and efficacy of three different doses of oral serlopitant compared to placebo for severe chronic pruritus in adults and children and found there was an absence of evidence.
Itch in psoriasis: epidemiology, clinical aspects and treatment options
The results confirmed the need for a global study of psoriasis with regard to both the cutaneous manifestations and the itch symptom and suggested biological therapies, mainly etanercept and efalizumab, proved useful in its control.
Pruritus in Burns: Review Article
The area of burns pruritus is under-researched and large-scale studies are required to reinforce the armamentarium of specialists with evidence-based regimens for the treatment of this highly distressing symptom.
Scar Symptoms: Pruritus and Pain
This chapter aims to outline the basic pathophysiological processes underlying pain and pruritus in scars and present a variety of options available for management of these symptoms.


Topical capsaicin therapy in humans with hemodialysis-related pruritus
Experimentally induced pruritus and cutaneous reactions with topical antihistamine and local analgesics in atopic eczema.
It is concluded that these substances, when applied for 15 min, are not sufficiently effective in atopic skin suppressing histamine-induced reactions under experimental conditions, and the diminished elicitation of alloknesis in these patients may be a result of central nervous system alteration.
Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin
It is concluded that capsaicin does effectively suppress histamine-induced itching in healthy skin but has less effect in AE, indicating that histamine is not the key factor in itching in AE.
Topical capsaicin treatment of chronic postherpetic neuralgia.
Botulinum toxin type A injection in the treatment of lichen simplex: an open pilot study.
It is concluded that lichen simplex-associated pruritus can be overcome by intradermal botulinum toxin A injection.
Treatment of aquagenic pruritus with topical capsaicin cream.
Randomized Controlled Trial of Topical Aspirin in the Treatment of Bee and Wasp Stings
Topical aspirin paste was not effective in reducing the duration of swelling or pain in bee and wasp stings, and significantly increased theduration of redness.
Itch--mediators and mechanisms.
  • M. Schmelz
  • Biology
    Journal of dermatological science
  • 2002
It is believed a revision and updating of the problem is now necessary, both from a pathophysiologic and a clinical point of view.
Treatment of notalgia paresthetica with topical capsaicin.
  • J. Wallengren
  • Medicine
    Journal of the American Academy of Dermatology
  • 1991