Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.

@article{Sigurdsson2007TopicalAS,
  title={Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.},
  author={H{\'a}kon Hrafn Sigurdsson and F{\'i}fa Konr{\'a}ethsd{\'o}ttir and Thorsteinn Loftsson and Einar Stef{\'a}nsson},
  journal={Acta ophthalmologica Scandinavica},
  year={2007},
  volume={85 6},
  pages={598-602}
}
PURPOSE This study aimed to: (1) determine the relative efficiencies of topical and systemic absorption of drugs delivered by eyedrops to the anterior and posterior segments of the eye; (2) establish whether dexamethasone-cyclodextrin eyedrops deliver significant levels of drug to the retina and vitreous in the rabbit eye, and (3) compare systemic absorption following topical application to the eye versus intranasal or intravenous delivery. METHODS In order to distinguish between topical and… CONTINUE READING

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