Topical and peripherally acting analgesics.

@article{Sawynok2003TopicalAP,
  title={Topical and peripherally acting analgesics.},
  author={Jana Sawynok},
  journal={Pharmacological reviews},
  year={2003},
  volume={55 1},
  pages={1-20}
}
Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the peripheral activation of primary sensory afferent neurons. The localized peripheral administration of drugs, such as by topical application, can potentially optimize drug concentrations at the site of origin of the pain, while leading to lower systemic levels and fewer adverse systemic effects, fewer drug interactions, and no need to titrate doses into a therapeutic range compared with systemic administration… CONTINUE READING
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