Topical administration of the antineoplastic carmustine: tolerance of normal rabbit eyes.

@article{Henriquez1981TopicalAO,
  title={Topical administration of the antineoplastic carmustine: tolerance of normal rabbit eyes.},
  author={Adolfo Henriquez and Lynne H. Liu and Miguel F Refojo},
  journal={Current eye research},
  year={1981},
  volume={1 3},
  pages={183-7}
}
We evaluated the tolerance of ocular tissues to topical application of the anticancer agent 1,3 bis(2-chloroethyl)-1-nitrosourea (carmustine, BCNU) in eight normal rabbit eyes. Early changes in the anterior ocular structures, including moderate to severe chemosis, lid swelling, and superficial punctate keratitis with epithelial defect and corneal edema… CONTINUE READING