Topical administration of simvastatin recovers alveolar bone loss in rats.

@article{Seto2008TopicalAO,
  title={Topical administration of simvastatin recovers alveolar bone loss in rats.},
  author={Hiroyuki Seto and Hirofumi Ohba and Keisuke Tokunaga and Hideki Hama and Mayumi Horibe and Toshihiko Nagata},
  journal={Journal of periodontal research},
  year={2008},
  volume={43 3},
  pages={261-7}
}
BACKGROUND AND OBJECTIVE Simvastatin, a cholesterol-lowering drug, has been reported to show anabolic effects on bone metabolism. We examined the effects of simvastatin in vitro using cultured rat calvaria cells and in vivo using periodontitis-induced rats. MATERIAL AND METHODS Alkaline phosphatase activity and bone nodule formation were measured in cultured rat calvaria cells. Nylon ligature was placed around the maxillary molars of Fischer male rats for 20 d to induce alveolar bone… CONTINUE READING