Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.

@article{He2015TopicalAO,
  title={Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.},
  author={Chang He and Chongzhen Yu and Lin Sun and Rashid M. Mahdi and Joseph M. Larkin and Charles E Egwuagu},
  journal={Journal of autoimmunity},
  year={2015},
  volume={62},
  pages={
          31-8
        }
}
Uveitis is a diverse group of potentially sight-threatening intraocular inflammatory diseases and pathology derives from sustained production of pro-inflammatory cytokines in the optical axis. Although topical or systemic steroids are effective therapies, their adverse effects preclude prolonged usage and are impetus for seeking alternative immunosuppressive agents, particularly for patients with refractory uveitis. In this study, we synthesized a 16 amino acid membrane-penetrating lipophilic… CONTINUE READING
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