Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia

  title={Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia},
  author={Y. Watanabe and Takashi Nagashima and N Hanzawa and Akihiro Ishino and Yosuke Nakazawa and Masashi Ogo and Tokuro Iwabuchi and Masahiro Tajima},
  journal={International Journal of Cosmetic Science},
Hair thickness is more important than hair density in the appearance of baldness in male with androgenetic alopecia (AGA). Adenosine improves hair loss by stimulating hair growth and by thickening hair shafts in women. The objective of this study was to evaluate the hair growth efficacy and safety of topical adenosine in men with AGA. 
Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia
Adenosine is effective in increasing the proportion of thick hair in Caucasian men with AGA as well as in Japanese men and women.
Topical niacinamide does not stimulate hair growth based on the existing body of evidence
New data is provided to demonstrate that Nam has a neutral, if any, impact on hair growth properties and to clarify misconceptions in the consumer world on the alleged side effects of niacinamide (Nam).
Transdermal delivery of a new hair growth promoting solution in patients with hair loss
It is found that all the patients had less hair loss and thicker hair after this treatment and additional placebo-controlled studies are needed to evaluate the efficacy of this combination treatment.
Efficacy and Safety of Topical Adenosine for Androgenetic Alopecia in Adults: A Systematic Review
Topical adenosine may be effective in increasing thick hair ratio and improving the self-perception of hair growth and with minimal to no adverse effects, it may serve as an adjunct or alternative to present treatment options.
Guidelines for the diagnosis and treatment of male‐pattern and female‐pattern hair loss, 2017 version
A revised version of the 2010 guidelines aimed at both MPHL and FPHL is reported, with finasteride 1 mg daily, dutasteride 0.5 mg daily and topical 5% minoxidil twice daily for MPHL, and topical 1% minxidil Twice daily for FPHL, recommended as the first‐line treatments.
Immunopotentiator from Pantoea agglomerans 1 (IP-PA1) Promotes Murine Hair Growth and Human Dermal Papilla Cell Gene Expression.
An underlying mechanism of gene expression by which IP-PA1 promotes hair growth was suggested to be different from that of medicine and traditional hair tonics, such as minoxidil and adenosine.
Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis
Oral nicotinamide should be considered in healthy patients or organ transplant recipients with history of skin cancer (GRADE: weak recommendation; moderate-quality evidence), in particular of BCC and cSCC.
Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells
The data demonstrate that niacinamide could enhance hair growth by preventing oxidative stress-induced cell senescence and premature catagen entry of hair follicles.
Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells
It is demonstrated that adenosine stimulates Wnt/β-catenin signaling through the activation of theAdenosine receptor and Gsk3β plays a critical role in transmitting the signals from the adenosines receptor to β- catenin, possibly via the Gαs/cAMP/PKA/mTOR signaling cascade.


Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men
The relative contributions of hair density and diameter to AGA are still unclear and the cause of balding in men is still unclear.
Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double‐blind, randomized, placebo‐controlled trial
Adenosine improved hair loss in Japanese women by stimulating hair growth and by thickening hair shafts and was significantly superior to the placebo according to assessments by dermatologists and investigators and by self‐assessment.
Alopecia Androgenetica — Its Incidence in Japanese and Associated Conditions
Hamilton (1951), in a frontier work, extensively studied the developing patterns of scalp hair in men and women from the prenatal period through the tenth decade, then compared the incidence of baldness between Caucasian and Chinese.
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