Topical acne treatments in Europe and the issue of antimicrobial resistance

@article{Leccia2015TopicalAT,
  title={Topical acne treatments in Europe and the issue of antimicrobial resistance},
  author={Marie Th{\'e}r{\`e}se Leccia and Nicole Auffret and Florence Poli and Jean Paul Claudel and St{\'e}phane Corvec and Brigitte Dr{\'e}no},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2015},
  volume={29}
}
  • M. LecciaN. Auffret B. Dréno
  • Published 1 August 2015
  • Biology, Medicine
  • Journal of the European Academy of Dermatology and Venereology
Acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by Propionibacterium acnes (P. acnes) as well as immune reactions and inflammation. Despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in Europe to treat acne. This intensive use led to… 

Reasonable selection of a topical therapy for different forms of acne

The facts of the effectiveness of Clenzit gel, an algorithm for the choice of drug depending on clinical and morphological features of the skin process that allows to optimize the treatment of patients with various forms of acne are presented.

Acne Vulgaris in Adults: A Brief Review on Diagnosis and Management

Acne vulgaris is a chronic skin disease with an inflammatory condition of the skin affecting the pilosebaceous glands, such as sebum production, follicular skin, microbial colonization by Propionibacterium acnes bacteria, and inflammatory mediators.

Recent advances in understanding ( Propionibacterium acnes ) in acne

The skin commensal , recently renamed Propionibacterium acnes , along with the other major pathophysiological factors Cutibacterium acnes of increased seborrhea, hyperkeratinization of the

Role Cutibacterium acnes při acne vulgaris

The role of Cutibacterium acnes in pathogenesis of acne vulgaris is covered, since recent studies propose that biofilm formation in the pilosebaceous unit by C. acnes is a major factor initiating the development of this disease.

Recent advances in understanding ( Propionibacterium acnes ) in acne Cutibacterium acnes

The skin commensal , recently renamed Propionibacterium acnes , along with the other major pathophysiological factors Cutibacterium acnes of increased seborrhea, hyperkeratinization of the

A comparison of the effectiveness of azelaic and pyruvic acid peels in the treatment of female adult acne: a randomized controlled trial

Both AA and PA peelings are a safe and efficient treatment for mild acne, however, during the selection of one of the two acids, side effects, skin properties, and patients’ preferences should be taken into account.

Recent advances in understanding Propionibacterium acnes ( Cutibacterium acnes) in acne

P. acnes plays a further important role in the homeostasis of the skin’s microbiome, interacting with other cutaneous commensal or pathogenic microorganisms such as Staphylococcus epidermidis, Streptococcus pyogenes, and Pseudomonas species.

Recent advances in understanding Propionibacterium acnes ( Cutibacterium acnes ) in acne [version 1; peer review: 2 approved]

P. acnes modulates the differentiation of keratinocytes by inducing keratin 10, filaggrin, and desmocollin 1 expression, resulting in the formation of inflammatory acne lesions, and plays a further important role in the homeostasis of the skin’s microbiome.

Profile of clindamycin phosphate 1.2%/benzoyl peroxide 3.75% aqueous gel for the treatment of acne vulgaris

A brief review of acne pathogenesis, benzoyl peroxide and clindamycin, and a profile of a new Clind amycin-BP 3.75% fixed combination gel for the treatment of moderate-to-severe acne vulgaris is provided.

References

SHOWING 1-10 OF 131 REFERENCES

Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris

The efficacy of BPO can be enhanced when used in combination with topical retinoids, antibiotics and tertiary amines and do not induce bacterial resistance and are important first-line treatments for mild to moderate acne vulgaris.

Pathogenesis of acne vulgaris: recent advances.

The discovery of P. acnes interaction with Toll-like receptors (TLRs), vaccines targeting P. Acnes or its components, antimicrobial peptides and the role of hormones were made.

Topical Drug Treatment in Acne

More and more evidence comes up that topical antiandrogenic agents will soon be available to treat the important factor seborrhea, because patients with marked hyperseborRhea frequently relapse.

Acne: topical treatment.

Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline

Although oral tetracycline was more effective than azelaic acid, the differences were only just significant and produced only a few minor side‐effects.

Antibiotic‐resistant acne: lessons from Europe

This data indicates that despite numerous reports of skin colonization by antibiotic‐resistant propionibacteria among acne patients, accurate prevalence data are available only for the U.K.

Benzoyl peroxide: enhancing antibiotic efficacy in acne management.

  • Maha Dutil
  • Biology, Medicine
    Skin therapy letter
  • 2010
Benzoyl peroxide has potent antibacterial and mild anti-inflammatory and comedolytic effects and can be used alone or in combination with topical antibiotics and topical retinoids to treat mild to moderate acne.

Antibiotic resistance of Propionibacterium acnes in acne vulgaris.

  • J. Swanson
  • Medicine, Biology
    Dermatology nursing
  • 2003
Improper use of antibiotics in the dermatological setting needs to be evaluated to prevent the increasing prevalence of antibiotic resistance.

Topical tretinoin in acne therapy.

  • G. Webster
  • Medicine
    Journal of the American Academy of Dermatology
  • 1998

An evaluation of dapsone gel 5% in the treatment of acne vulgaris

Clinical studies indicate dapsone gel 5% is effective in treating mild to moderately severe acne, and pharmacokinetic evidence indicating topical dosing in comparison to oral administration significantly reduces systemic concentrations of the drug, and therefore risk of serious side effects.
...