Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivo

  title={Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivo},
  author={Martin Schmelz and Simone Weber and Michaela Kress},
  journal={Neuroscience Letters},

The effect of topically applied salicylic compounds on serotonin‐induced scratching behaviour in hairless rats

It is concluded that topical application of diethylamine salicylate and salicylamide could suppress serotonin‐induced scratching in rats and the antipruritic effect seems to be related to the slow drug release of the two substances.

Prostaglandin E2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls.

It is concluded that PGE(2) is a potent vasodilator and a weak pruritic agent in normal skin and in patients with AD, but does not provoke increased protein extravasation.

Microdialysis of inflammatory mediators in the skin: a review.

This review provides a comprehensive but not exhaustive review of the use of microdialysis in studies of experimental and clinical inflammatory reactions in the skin in animals and humans.

Microdialysis Sampling for Investigations of Bioavailability and Bioequivalence of Topically Administered Drugs: Current State and Future Perspectives

An overview of the current state and future perspectives of dermal MD sampling is given and an in-depth discussion of the application of MD for the evaluation of bioavailability and bioequivalence of topical formulations is concluded.

Assessment of cutaneous drug delivery using microdialysis.

Modern aspects of cutaneous neurogenic inflammation.

The role of nerves in mediating cutaneous inflammation is discussed and the mechanisms and the factors controlling neuromediators and their receptors and degrading enzymes will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases.



Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus

  • S. Manzini
  • Biology, Chemistry
    British journal of pharmacology
  • 1992
The mouse main bronchus appears to be a monoreceptorial tissue containing only NK1 receptors which subserve bronchodilator functions and the consequent relaxation is probably mediated by the generation of prostanoids.

Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.

It is suggested that the inflammatory mediators, bradykinin,5-HT, and prostaglandin E2 together act as endogenous mediators at capsaicin receptors to generate an inward current when the ion channel is protonized.

The actions of capsaicin applied topically to the skin of the rat on C‐fibre afferents, antidromic vasodilatation and substance P levels

It is suggested that the ability of relatively low concentrations of Capsaicin to desensitize C‐fibre nociceptors may underlie the analgesic action of topical capsaicin in man.

Microvascular leakage induced by substance P in rat urinary bladder: involvement of cyclo-oxygenase metabolites of arachidonic acid.

It is indicated that intravascular SP promotes plasma exudation in rat urinary bladder through an NK1-mediated effect on venular permeability and the release of cyclo-oxygenase metabolites of arachidonic acid.

Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres.

Differential capsaicin sensitivity adds to the cumulating evidence for the existence of two categories of functionally different nociceptors in human skin, with a special role for mechano-insensitive fibres in sensitization and hyperalgesia.