Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice

@article{Pozsgai2007TopicalAT,
  title={Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice},
  author={G{\'a}bor Pozsgai and Katalin S{\'a}ndor and Anik{\'o} Perkecz and J{\'a}nos Szolcs{\'a}nyi and Zsuzsanna Helyes and Susan Diana Brain and Erika Pint{\'e}r},
  journal={Inflammation Research},
  year={2007},
  volume={56},
  pages={459-467}
}
The participation of sensory neurons and transient receptor potential vanilloid 1 (TRPV1) receptors in phorbol 12-myristate 13-acetate (PMA)-induced nerve-sensitizing effect was examined. PMA dissolved in acetone and acetone were applied to the ears of TRPV1 receptor knockout and wild-type mice. Different groups of animals received ibuprofen, anti-interleukin-1 beta (IL-1β) antibody, resiniferatoxin (RTX) or capsaicin pretreatment. Ear thickness, myeloperoxidase activity and IL-1β content of… CONTINUE READING

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