Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis.

@article{Kim2016TopicalTO,
  title={Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis.},
  author={Mi Hye Kim and You Yeon Choi and Ji Eun Lee and Kyuseok Kim and Woong Mo Yang},
  journal={Planta medica},
  year={2016},
  volume={82 1-2},
  pages={
          65-9
        }
}
Formononetin is one of the main components of red clover plants and its role on hair regrowth against hair loss has not been established yet. In the present study, we assessed the potential effects of formononetin on alopecia, along with impaired hair cycles by induction of apoptosis-regression.Depilated C57BL/6 mice were used for monitoring the hair cycles. Formononetin (1 and 100 µM) was topically treated to the dorsal skin for 14 days. Topical formononetin treatment induced miniaturized hair… 

Figures from this paper

Is There Scientific Evidence that Panax Promotes Hair Growth?

TLDR
The results indicate that Panax ginseng has stood out as a promising natural source with relevant effects in treatment of hair loss, despite the small number of publications selected involving the keywords “Panax gINSeng” AND “hair loss”.

The Promoting Effect of Rumex japonicas Houttuyn ethanol extract on Hair Growth

Hair loss is dramatically growing trend to modern civilized people, and can be occurred by hereditary causes, aging, diseases, malnutrition, psychological stress, hormonal imbalances, etc.

Targeting Oct2 and P53: Formononetin prevents cisplatin‐induced acute kidney injury

Proliferation Effects on Hair Growth of Compounds Isolated from the Bark of Dalbergia oliveri

TLDR
One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2–11) were isolated from the bark of Dalbergia oliveri Prain and significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry

TLDR
The objective of the present review is to compile and update the published data on traditional uses, pharmacological potential, and phytochemistry of compounds isolated from the plant Pueraria tuberosa, which possesses an extensive range of pharmacological activities.

Formononetin: A Pathway to Protect Neurons

TLDR
The significant neuroprotective function of FMN makes it a novel candidate for the development of drugs targeting the central nervous system, and a literature search is conducted to provide information on the signaling pathways of neuroprotection of formononetin based on the neuroProtective study.

References

SHOWING 1-10 OF 31 REFERENCES

Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling.

TLDR
Findings reveal a role of A. sinensis as an alternative treatment for hair loss that acts through hair cycle pathways associated with apoptosis regression during catagen and restores the lengths of hair shafts and size of hair follicles.

Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling

TLDR
Results demonstrated that Astragaloside IV is concerned with blocking the Fas/Fas L-mediated apoptotic pathway, which would be an alternative therapy for hair loss.

Analysis of apoptosis during hair follicle regression (catagen)

TLDR
Select receptors of the tumor necrosis factor/nerve growth factor family and members of the Bcl-2 family may also play a key role in the control of follicular keratinocyte apoptosis in situ.

p53 is essential for chemotherapy-induced hair loss.

TLDR
It is demonstrated that p53 is essential for chemotherapy-induced hair loss, and observations indicate that local pharmacological inhibition of p53 may be useful to prevent chemotherapy-associated hair loss.

Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes.

TLDR
It is shown that calcineurin activity is associated with hair keratinocyte differentiation in vivo, affecting nuclear factor of activated T cells (NFAT1) activity in these cells in vivo by CsA, providing the first evidence that calcinesurin is functionally active in follicular keratinocytes.

Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss.

TLDR
The data suggest that chemotherapy induces a complex response in the hair follicle melanocytes, which includes apoptosis, proliferation, and migration, which might be useful for the correction of skin hyperpigmentation as a side-effect of chemotherapy.

The therapeutic use of topical minoxidil.

Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover).