Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis.

  title={Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis.},
  author={Mi Hye Kim and You Yeon Choi and Ji Eun Lee and Kyuseok Kim and Woong Mo Yang},
  journal={Planta medica},
  volume={82 1-2},
Formononetin is one of the main components of red clover plants and its role on hair regrowth against hair loss has not been established yet. In the present study, we assessed the potential effects of formononetin on alopecia, along with impaired hair cycles by induction of apoptosis-regression.Depilated C57BL/6 mice were used for monitoring the hair cycles. Formononetin (1 and 100 µM) was topically treated to the dorsal skin for 14 days. Topical formononetin treatment induced miniaturized hair… 

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  • Y. YeR. Hou Z. Mo
  • Biology
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2012
The induced apoptosis effect of formononetin on human prostate cancer cells was related to ERK1/2 MAPK-Bax pathway, which resulted in increased the expression levels of BCL2-associated X (Bax) mRNA and protein, andinduced apoptosis in LNCaP cells.