Topical Treatment of Experimental Hydrofluoric Acid Skin Burns by 2.5% Calcium Gluconate

@article{Roblin2006TopicalTO,
  title={Topical Treatment of Experimental Hydrofluoric Acid Skin Burns by 2.5\% Calcium Gluconate},
  author={Isabelle Roblin and M Urban and Domitille Flicoteau and C Martin and Dominique Pradeau},
  journal={Journal of Burn Care \& Research},
  year={2006},
  volume={27},
  pages={889-894}
}
Topical therapy with 2.5% calcium gluconate gel is considered as the “first-aid” treatment of accidental hydrofluoric acid skin burns. The efficacy of three different gel formulations varying in the amount and/or nature of their gelling and moisturizing agents was experimentally evaluated. Thirty male Wistar-Han rats (250 g) were exposed to 60 &mgr;l of 40% hydrofluoric acid for 2 minutes on two spots (4 cm2) of skin under pentobarbital anesthesia. One lesion was massaged with 1 g of gel (10… 
View on Wolters Kluwer
ncbi.nlm.nih.gov
29 Citations
Background Citations
8
Methods Citations
1

29 Citations

Comparison of skin effects of immediate treatment modalities in experimentally induced hydrofluoric acid skin burns
TLDR
EGF limited HF damage morphologically and histologically more effectively than Ca2+ or Mg2+.
Subcutaneous injection of epidermal growth factor for skin hydrofluoric acid burns
TLDR
The authors have compared the effect of epidermal growth factor injection on skin hydrofluoric acid (HF) burns with those of magnesium sulphate and calcium gluconate injections, indicating that EGF limited HF damage morphologically and histologically, more effectively than Ca2+ or Mg2+.
Hydrofluoric Acid Burns: A Case Report
TLDR
Immediate cleansing of the affected area with running cold water is the first critical treatment for a chemical burn due to HF, and applying calcium gluconate gel within one hour was very effective for preventing further damage to the injured area as well as systemic injury.
A review of treatment strategies for hydrofluoric acid burns: current status and future prospects.
Importance of initial management and surgical treatment after hydrofluoric acid burn of the finger.
Clinical findings, treatment and resolution of Simplex® toxicity in three horses
TLDR
Three horses presented two hours after accidental ingestion of plants contaminated with Simplex®, showing a moderate impairment of their general condition, appeared sedated with intestinal hypomotility and showed symptoms of marked conjunctival irritation, which are the first documented clinical cases of Simplex® toxicity in horses.
Water-based solutions are the best decontaminating fluids for dermal corrosive exposures: A mini review
TLDR
The data support water as the best decontaminating solution, which has been shown to be efficacious in clinical trials, is widely available, and inexpensive.
Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze-thawing, and its application in wound care.
Recommended Medical Treatment for Hydrofluoric Acid Exposure
This Booklet describes the special First Aid and Medical Treatment measures necessary following exposure to or injury from HYDROFLUORIC ACID. PREVENTION of exposure or injury must be the primary…
Hydrofluoric acid inhalation injury.
TLDR
A case of a patient who presented with a severe inhalation injury who survived and this case highlights the extreme complexity of managing this kind of injury and the need for more experimental research to develop better treatment options.
...
...

References

SHOWING 1-10 OF 20 REFERENCES
Therapeutic effect of topical calcium gluconate for hydrofluoric acid burn--time limit for the start of the treatment.
TLDR
It is suggested that practitioners should be ready to prepare quickly the calcium gluconate ointment to treat a HF burn, since the calciumgluconates is not commercially available in Japan.
Comparative effectiveness of topical treatments for hydrofluoric acid burns.
TLDR
Calcium gluconate ointment was the most effective topical treatment for HF burns and significant protection continued for seven days after the single application.
A study to determine the efficacy of treatments for hydrofluoric acid burns.
TLDR
Results indicate that subcutaneous injections of magnesium or calcium salts appear to be more effective than conventional topical applications in the treatment of hydrofluoric acid burns and that topically applied calcium gluconate combined with a penetration enhancer, such as dimethyl sulfoxide, is as effective as injection treatments in reducing damage caused by hydrofluic acid.
Comparison of topical magnesium and calcium treatment for dermal hydrofluoric acid burns.
Hydrofluoric acid dermal burns. An assessment of treatment efficacy using an experimental pig model.
  • B. Dunn, M. MacKinnon, R. Dahlgren
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1992
TLDR
This study suggests that the anesthetized pig model has good applicability for assessing efficacy of HF dermal burn therapies, and indicates that further experimentation with 10% calcium acetate soaks is warranted.
Hydrofluoric acid burns of the hand: mechanism of injury and treatment.
Rationale of the treatment of hydrofluoric acid burns
TLDR
Using a specific ion electrode for fluoride, the efficacy of calcium, magnesium and lanthanum salts and hyamine in lowering fluoride ion concentration in the presence of serum was examined and Lanthanum was the most effective but was itself toxic to skin cells as judged by respiration and tetrazolium reductase measurements.
Medical management of hydrofluoric acid exposure.
  • M. Upfal, C. Doyle
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1990
TLDR
Inhalation, ingestion, and ocular exposures require specialized treatment and referral, and life-threatening alterations of electrolytes can occur, with ensuing arrhythmias.
Hydrofluoric acid: a review of toxicity.
Hydrofluoric acid-induced hypocalcemia.
TLDR
Treatment of two survivors, apparently the first two, of severe hypocalcemia caused by hydrofluoric acid is described, both intravenously and by subsechar injection, to replenish the biologically active calcium and to bind fluoride.
...
...