Topical Treatment With Bromfenac Reduces Retinal Gliosis and Inflammation After Optic Nerve Crush.

@article{Rovere2016TopicalTW,
  title={Topical Treatment With Bromfenac Reduces Retinal Gliosis and Inflammation After Optic Nerve Crush.},
  author={Giuseppe Rovere and F. Nadal-Nicol{\'a}s and P. Sobrado-Calvo and D. Garc{\'i}a-Bernal and M. P. Villegas-Perez and M. Vidal-Sanz and M. Agudo-Barriuso},
  journal={Investigative ophthalmology & visual science},
  year={2016},
  volume={57 14},
  pages={
          6098-6106
        }
}
  • Giuseppe Rovere, F. Nadal-Nicolás, +4 authors M. Agudo-Barriuso
  • Published 2016
  • Medicine
  • Investigative ophthalmology & visual science
  • Purpose To study the effect of topical administration of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID), on retinal gliosis and levels of prostaglandin E2 (PGE2) after complete optic nerve crush (ONC). Methods Adult albino rats were divided into the following groups (n = 8 retinas/group): (1) intact, (2) intact and bromfenac treatment (twice a day during 7 days), (3) ONC (7 days), and (4) ONC (7 days) + bromfenac treatment (twice a day during 7 days). Animals from groups 3 and 4… CONTINUE READING
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