Topical Therapy for Osteoarthritis: Clinical and Pharmacologic Perspectives

@article{Altman2009TopicalTF,
  title={Topical Therapy for Osteoarthritis: Clinical and Pharmacologic Perspectives},
  author={R. Altman and R. Barkin},
  journal={Postgraduate Medicine},
  year={2009},
  volume={121},
  pages={139 - 147}
}
Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown efficacy in patients with osteoarthritis (OA) pain but are also associated with a dose-dependent risk of gastrointestinal, cardiovascular, hematologic, hepatic, and renal adverse events (AEs). Topical NSAIDs were developed to provide analgesia similar to their oral counterparts with less systemic exposure and fewer serious AEs. Topical NSAIDs have long been available in Europe for the management of OA, and guidelines of the… Expand
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