Topical Retinoids in Acne Vulgaris: A Systematic Review

@article{Kolli2019TopicalRI,
  title={Topical Retinoids in Acne Vulgaris: A Systematic Review},
  author={S S Kolli and Danielle Pecone and Adrian Pona and Abigail Cline and Steven R. Feldman},
  journal={American Journal of Clinical Dermatology},
  year={2019},
  volume={20},
  pages={345-365}
}
BackgroundTopical retinoids are a first-line treatment for acne vulgaris.ObjectiveThis systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.MethodsA PubMed and Embase search was conducted using the search terms ‘adapalene,’ ‘tretinoin,’ ‘tazarotene,’ and ‘acne vulgaris.’ Selection of articles fit the following inclusion criteria: clinical trials evaluating both efficacy and safety… 
Dermatology: how to manage acne vulgaris
TLDR
Topical retinoids are the drugs of choice for the treatment and maintenance therapy of patients with mild-to-moderate acne vulgaris and may be used alone or in combination with benzoyl peroxide and topical or oral antibiotics.
Adverse events related to topical drug treatments for acne vulgaris
TLDR
The most commonly reported AEs were associated with local skin irritation, usually mild to moderate in intensity, intermittent, and rarely led to the cessation of therapy, which seems to be highest for BPO and topical retinoids.
Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems
TLDR
There is a clear need to target delivery of the retinoids to the pilosebaceous units to increase efficacy and minimise side effects in surrounding skin tissue.
50 Years of Topical Retinoids for Acne: Evolution of Treatment
TLDR
This qualitative literature review summarizes the evolution of the four topical single-agent retinoids available for the treatment of acne in the US today and their various formulations, presenting the rationale behind their development and data from key studies.
Topical benzoyl peroxide for acne.
TLDR
Based on low-certainty evidence, there may be little to no difference between BPO and adapalene, and for 'participant-reported acne improvement', BPO may be more effective than placebo or no treatment.
Guidance for the pharmacological management of acne vulgaris
TLDR
The author discusses the treatment of comedonal, papulopustular, and nodular/cystic/conglobate acne and proposes a simplified treatment escalation strategy that is based on disease severity and extension.
Trifarotene for the Treatment of Facial and Truncal Acne
TLDR
Trifarotene is a newly Food and Drug Administration–labeled fourth-generation topical retinoid that shows particular promise in the treatment of facial and truncal acne vulgaris and is an effective and safe addition to currently available retinoids.
Management of Acne Vulgaris: A Review.
TLDR
Isotretinoin is approved by the US Food and Drug Administration for treating severe recalcitrant nodular acne but is often used to treat resistant or persistent moderate to severe acne, as well as acne that produces scarring or significant psychosocial distress.
Impact of Parallel Topical Treatment with Nadifloxacin and Adapalene on Acne Vulgaris Severity and Quality of Life: A Prospective, Uncontrolled, Multicentric, Noninterventional Study
TLDR
In this study, the parallel use of adapalene and nadifloxacin for at least 5 weeks resulted in a rapid improvement in acne severity, an increase in HRQoL, and a good safety profile and represents a promising treatment option that offers the possibility of flexible therapy adjustment.
Assessing the Safety and Efficacy of Trifarotene in the Treatment of Acne Vulgaris
TLDR
This narrative review summarizes all currently available literature regarding the use of trifarotene in acne vulgaris and focuses on efficacy, safety, and tolerability data and highlight quality of life outcomes and patient-reported satisfaction.
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TLDR
Adapalene gel was associated with fewer reports of cutaneous irritation, particularly for scaling and stinging/burning, and fewer treatment-related adverse events compared to switch therapy, demonstrating the noninferiority of adapalenes gel treatment.
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The efficacy and safety of the combination therapy of nadifloxacin cream with adapalene gel for the inflammatory acne was showed and the combination did not elevate the side effects of erythema and scale scores, but rather significantly depressed ery thema at 1 week.
Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems
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There is a clear need to target delivery of the retinoids to the pilosebaceous units to increase efficacy and minimise side effects in surrounding skin tissue.
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Based on low-certainty evidence, there may be little to no difference between BPO and adapalene, and for 'participant-reported acne improvement', BPO may be more effective than placebo or no treatment.
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This study compares the efficacy and safety of two common topical treatment regimens in the treatment of a moderate to severe facial acne vulgaris and found regimen BPO/C+RAM yielded a more rapid onset of effect versus regimen CPT+BPO against both non-inflammatory and inflammatory lesions.
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