Topical Retinoids in Acne Vulgaris: A Systematic Review
@article{Kolli2019TopicalRI, title={Topical Retinoids in Acne Vulgaris: A Systematic Review}, author={S S Kolli and Danielle Pecone and Adrian Pona and Abigail Cline and Steven R. Feldman}, journal={American Journal of Clinical Dermatology}, year={2019}, volume={20}, pages={345-365} }
BackgroundTopical retinoids are a first-line treatment for acne vulgaris.ObjectiveThis systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.MethodsA PubMed and Embase search was conducted using the search terms ‘adapalene,’ ‘tretinoin,’ ‘tazarotene,’ and ‘acne vulgaris.’ Selection of articles fit the following inclusion criteria: clinical trials evaluating both efficacy and safety…
43 Citations
Dermatology: how to manage acne vulgaris
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- 2021
Topical retinoids are the drugs of choice for the treatment and maintenance therapy of patients with mild-to-moderate acne vulgaris and may be used alone or in combination with benzoyl peroxide and topical or oral antibiotics.
Adverse events related to topical drug treatments for acne vulgaris
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The most commonly reported AEs were associated with local skin irritation, usually mild to moderate in intensity, intermittent, and rarely led to the cessation of therapy, which seems to be highest for BPO and topical retinoids.
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There is a clear need to target delivery of the retinoids to the pilosebaceous units to increase efficacy and minimise side effects in surrounding skin tissue.
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This qualitative literature review summarizes the evolution of the four topical single-agent retinoids available for the treatment of acne in the US today and their various formulations, presenting the rationale behind their development and data from key studies.
Topical benzoyl peroxide for acne.
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- 2020
Based on low-certainty evidence, there may be little to no difference between BPO and adapalene, and for 'participant-reported acne improvement', BPO may be more effective than placebo or no treatment.
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The author discusses the treatment of comedonal, papulopustular, and nodular/cystic/conglobate acne and proposes a simplified treatment escalation strategy that is based on disease severity and extension.
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Trifarotene is a newly Food and Drug Administration–labeled fourth-generation topical retinoid that shows particular promise in the treatment of facial and truncal acne vulgaris and is an effective and safe addition to currently available retinoids.
Management of Acne Vulgaris: A Review.
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Impact of Parallel Topical Treatment with Nadifloxacin and Adapalene on Acne Vulgaris Severity and Quality of Life: A Prospective, Uncontrolled, Multicentric, Noninterventional Study
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In this study, the parallel use of adapalene and nadifloxacin for at least 5 weeks resulted in a rapid improvement in acne severity, an increase in HRQoL, and a good safety profile and represents a promising treatment option that offers the possibility of flexible therapy adjustment.
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This narrative review summarizes all currently available literature regarding the use of trifarotene in acne vulgaris and focuses on efficacy, safety, and tolerability data and highlight quality of life outcomes and patient-reported satisfaction.
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