Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

  title={Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin},
  author={Ryan R. Riahi and Amelia E Bush and Philip R. Cohen},
  journal={American Journal of Clinical Dermatology},
Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including photoaging. Photodamage of the skin occurs as a consequence of cumulative exposure to solar ultraviolet radiation (UVR) and is characterized by deep wrinkles, easy bruising, inelasticity, mottled… 

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A brief retrospective of the development of topical retinoids in the treatment of photodamaged skin, elucidates their mechanism of action, delineates their use and addresses clinical, pharmaceutical and regulatory issues in connection with their intended use is provided.

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The role of retinoids in the prevention and repair of aged and photoaged skin

  • C. Griffiths
  • Medicine, Biology
    Clinical and experimental dermatology
  • 2001
Emerging evidence indicates that intrinsic, chronological ageing of the skin shares several mechanistic features with photoageing, and aged skin is characterized by retinoid sensitivity and is probably reparable by application of topical retinoids.

Photoaging: pathogenesis, prevention, and treatment.

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The safety and efficacy of topical alitretinoin gel 0.1% was well tolerated by participants and subjectively showed improvement of benign skin lesions and precancerous lesions, suggesting the role of this novel retinoid in the treatment of photoaging is still under investigation.

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