Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

@article{Riahi2016TopicalRT,
  title={Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin},
  author={Ryan R. Riahi and Amelia E Bush and Philip R. Cohen},
  journal={American Journal of Clinical Dermatology},
  year={2016},
  volume={17},
  pages={265-276}
}
Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including photoaging. Photodamage of the skin occurs as a consequence of cumulative exposure to solar ultraviolet radiation (UVR) and is characterized by deep wrinkles, easy bruising, inelasticity, mottled… 
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54 Citations
Highly Influential Citations
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54 Citations

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There is a lack of evidence from properly designed clinical trials to support the claimed efficacy of the most commonly used retinoids as antiaging agents in cosmeceuticals, but the promising potential of retinoid nanoformulations requires a more comprehensive evaluation with additional studies to supportThe preliminary findings.

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Effect of Topical Fluorouracil Cream on Photodamage: Secondary Analysis of a Randomized Clinical Trial

This study did not demonstrate improvement in photoaging with a standard course of topical fluorouracil, 5%, cream, a finding that may be attributable to a true lack of effect in photodamage or limitations of the photonumeric scales in capturing the effect.

Protective Effect of Potentilla glabra in UVB-Induced Photoaging Process

Since Pg-EE can improve skin barrier, hydration and reduce the UVB-induced inflammation on skin, it could therefore be a valuable natural ingredient for cosmetics or pharmaceuticals to treat skin disorders.

Encapsulation and controlled release of retinol from silicone particles for topical delivery

Targeting Angiogenesis by Blocking the ATM–SerRS–VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth

All-trans retinoic acid can directly induce the expression of a newly identified potent anti-angiogenic factor, seryl tRNA synthetase (SerRS), whose angiostatic role can be inhibited by UV-activated ataxia telangiectasia mutated (ATM) kinase.

Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation

It is demonstrated for the first time that a pair of known antiaging ingredients applied rotationally, on human dermal fibroblasts, maximized pro-collagen I production and rotational regimen using retinol and PGA is effective in treating facial photoaging signs with long-lasting benefits.

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