Topical L-ascorbic acid: percutaneous absorption studies.

  title={Topical L-ascorbic acid: percutaneous absorption studies.},
  author={Sheldon R. Pinnell and H Yang and Mahamarowi Omar and Nancy A Monteiro-Riviere and Holly V DeBuys and Linda C Walker and Yahzen Wang and Martine Levine},
  journal={Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]},
  volume={27 2},
BACKGROUND Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. OBJECTIVE This study defines formulation characteristics for delivering L-ascorbic acid into the skin to supplement the skin's natural antioxidant reservoir. METHODS L-ascorbic acid or its derivatives were applied to pig skin. Skin levels of L-ascorbic acid were measured to determine percutaneous delivery. RESULTS L… CONTINUE READING
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