Topical Ivermectin: A New Successful Treatment for Scabies

  title={Topical Ivermectin: A New Successful Treatment for Scabies},
  author={Jairo Victoria and R Trujillo},
  journal={Pediatric Dermatology},
Abstract: Ivermectin is the only one of the avermectins that has been widely used in humans, since it is recommended as the treatment of choice for onchocerciasis, a filariasis that produces “river blindness,” a parasitic endemic infestation in countries of West Equatorial Africa and in some areas of Central and South America. Also, ivermectin has been used for treating human endo‐ and ectoparasites with effective results and with almost no side effects. To study the efficacy of ivermectin for… 

Topical ivermectin versus crotamiton cream 10% for the treatment of scabies

Ivermectin was quite safe in the authors' cases and was as effective as single applications of crotamiton 10% cream at the 2‐week follow‐up, and after repeating the treatment, ivermECTin was superior to croTamiton cream 10% at the 4‐weekFollow‐up.

The scourge of sarcoptes: oral ivermectin for scabies.

  • D. Guay
  • Medicine
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists
  • 2004
Oral ivermectin may prove to be a time- and labor-saving alternative to topical scabicide treatments, especially in the institutional setting where labor shortages make the management of scabies outbreaks a true challenge.

Treatment of 18 children with scabies or cutaneous larva migrans using ivermectin

ivermectin is a safe and effective alternative treatment of cutaneous parasitosis in children and there is concern regarding the safety of its use in children under 5’years of age or weighing less than 15’kg.

Safety and efficacy of pediculicides for head lice

Assessment of topical lice therapies requires standardised in vitro testing and, based on concerns about safety and decreasing efficacy due to resistance, a reassessment of the general topic of pediculicides for head lice is warranted.

Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies.

Permethrin and topical ivermectin were equally effective against scabies while oral iver mectin was significantly less effective up to 2 weeks and can be used as an alternative to permethrin.

Topical treatment of tungiasis: a randomized, controlled trial

Results show that topical ivermectin, metrifonate or thiabendazole can each significantly reduce the number of lesions caused by embedded sand fleas.

Oral Ivermectin Treatment in Two Cases Of Scabies: Effective in Crusted Scabies Induced by Corticosteroid but Ineffective in Nail Scabies

Oral ivermectin is effective for crusted scabies, but not effective for nail scabies; two doses of oral iver mectin, administered with a one‐week interval, is an appropriate treatment regimen.

Clinical applications of topical ivermectin in dermatology.

The current applications of topical IVM in dermatology are reviewed and it is suggested that IVM may be useful in inflammatory cutaneous disorders such as papulopustular rosacea where demodex may play a role in pathogenesis.

In vitro susceptibility of Sarcoptes scabiei var. hominis to 1% topical ivermectin

Topical 1% ivermectin is effective against Sarcoptes scabiei in terms of in vitro susceptibility, which was significant.

Clinical efficacy and safety of topical versus oral ivermectin in treatment of uncomplicated scabies

It is suggested that both topical and oral ivermectin are safe and equally effective in treatment of uncomplicated scabies and repeating treatment after one week may be required to achieve 100% cure.



Efficacy of ivermectin in the therapy of larva currens.

Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recommended therapy for strongyloidiasis is oral tiabendazole or albendazole, but the former is poorly

Topical application of ivermectin for human ectoparasites.

In patients with scabies, the drug was also found to be effective after a single application of Ivernectin, but in 50% of the cases, another application was needed five days later.

Efficacy of ivermectin for the treatment of head lice (Pediculosis capitis).

It is suggested that ivermectin is a promising treatment of head lice, and a second dose at day 10 should be appropriate for a further comparative trial.

[Clinical effects of ivermectin in the treatment of Sarcoptes scabiei var canis in farm foxes].

ivermectin was a good alternative in the therapy of the Sarcoptes mange in foxes by moderate mite infection and a progressive clinical improvement of the mange lesions was evident in the treated foxes.

Ivermectin treatment in severe asymmetric reactive onchodermatitis (sowda) in Sudan.

Efficacy of topically administered ivermectin against chorioptic and sarcoptic mange of cattle

Treatment with ivermectin solution at a dose rate of 500 micrograms/kg bodyweight topically once was fully effective against C bovis and S scabiei when applied to healthy skin and impaired when the formulation was applied over areas of severe lesions caused by this parasite.

A Risk-Benefit Assessment of Agents Used in the Treatment of Scabies

It is important to stress that all household and sexual contacts must be treated, whether or not they have symptoms, and proper application of topical medications must be achieved, including under the fingernails and up to the edge of all body orifices.

Effect of mass treatments with ivermectin, with only partial compliance, on prevalence and intensity of O. volvulus infection in adults and in untreated 4 and 5 year‐old children in Burundi

  • E. Newell
  • Medicine
    Tropical medicine & international health : TM & IH
  • 1997
It appears that even a suboptimal mass distribution of ivermectin can reduce the microfilarial load to a level where the transmission of O. volvulus becomes seriously affected.

[A study in the Ivory Coast (1985-1987) of the efficacy and tolerance of ivermectin (Mectizan) in human onchocerciasis. III. The tolerance and efficacy of a single oral dose of 150 mcg/kg in children].

The administration of ivermectin is an efficient and well tolerated drug in children above 5 years old and in the cornea and anterior chamber there was a very reduced number of microfilariae still present.

Dermatological problems of onchocerciasis in Nebbi District, Uganda.

Given the prospects of onchocerciasis control based on mass ivermectin distribution in communities where blindness is common, it is recommended that treatment be extended to communitiesWhere blindness is less common, but skin disease known to be predominant.