Topical Corticosteroids and the Risk of Diabetes Mellitus

  title={Topical Corticosteroids and the Risk of Diabetes Mellitus},
  author={Michiel W. van der Linden and Fernie J. A. Beest and Tamar Nijsten and Ron M C Herings},
  journal={Drug Safety},
AbstractBackground: The relationship between topical corticosteroid use, potency, treatment duration, concomitant exposure to systemic corticosteroids, and risk of diabetes has been incompletely studied. Objective: To investigate an association between intense, longstanding topical corticosteroid use and diabetes mellitus. Methods: Data for this nested case-control study were obtained from the PHARMO Record Linkage System, including linked drug dispensing and hospital records of >2.5 million… 
Topical corticosteroids and risk of diabetes mellitus: systematic review and meta-analysis
A potential association between topical corticosteroid use and risk of developing type 2 diabetes mellitus is found, but this risk does not appear to be dependent on potency of the topical medication, but rather the cumulative dose and cumulative duration of use.
Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts
A positive association between topical CS prescribing and incident T2D in Danish and U.K. adult populations is found, and Clinicians should be cognizant of possible diabetogenic effects of potent topical CSs.
Topical corticosteroids and type 2 diabetes mellitus: a critical appraisal
This data indicates that topical corticosteroid use for psoriasis and eczema, which affect 2-3% and 2-8% of adults worldwide, respectively, is associated with an increased risk of newly-diagnosed type 2 diabetes.
Acute Hyperglycemia Due to Topical Corticosteroid Administration
This is to the authors' knowledge the first case reported in which a 71-year-old man with longstanding, previously well-controlled type 1 diabetes required a very significant amount of extra insulin after using high potency topical steroid cream.
Management of cardiovascular disease in patients with psoriasis
The evidence associating psoriasis with CV disease, as well as the pharmacological and non-pharmacological treatment of CV risk factors including the CV effects of anti-psoriatic therapy and vice versa are described.
A study of steroid-induced diabetes mellitus in leprosy.
There were significantly more LL/BL patients with positive BI among SID whose cumulative prednisolone dosage was nearly 9000 mg as compared to half the amount among others.
Overt diabetes mellitus caused by the topical administration of dexamethasone ointment on the oral mucosa.
We herein describe the case of a 68-year-old man who developed overt diabetes mellitus following the topical administration of dexamethasone 0.1%-containing ointment over a five-month period to treat
Syddansk Universitet The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis a systematic review and meta-analysis
While adults with AD in some populations have increased prevalence of cardiovascular risk factors, such as obesity and smoking, it is unlikely that AD represents an independent and clinically relevant risk factor for cardiometabolic disease.
Topical corticosteroids in dermatology
Since their introduction, topical corticosteroids have become indispensable in the treatment of various dermatoses and various adverse effects often occur as an extension of their activity combined with inappropriate usage.
Evolution of bone mineral density in patients treated with high-dose topical corticosteroids for a bullous pemphigoid
The results suggest larger studies to analyse links between high dose of topical corticosteroids and osteoporosis in patients with BP, and changes in BMD and biological markers according to the dose of clobetasol propionate in Patients with BP.


Inhaled corticosteroids and the risk of diabetes among the elderly.
The results do not indicate an increased risk of diabetes among current users of inhaled corticosteroids, and the possibility of a dose-response relationship in users of beclomethasone is investigated.
Quantification of the risk of corticosteroid-induced diabetes mellitus among the elderly
The estimated number needed to harm for continuous use of oral corticosteroids relative to PPIs over 1, 2, and 3 years of use were 41, 23, and 16, respectively.
Topical corticosteroids in atopic dermatitis
  • D. Atherton
  • Medicine, Biology
    BMJ : British Medical Journal
  • 2003
The recent development of the topical immuno-modulators, tacrolimus and pimecrolimus, has provided alternatives to topical corticosteroids, but these remain expensive and are not effective in every case.
Topical Corticosteroid-Induced Adrenocortical Insufficiency
Since nonreversible clinical secondary adrenocortical-insufficiency disease has not been clearly documented with even class I topical corticosteroids, native adrenal supplementation in periods of stress appears unnecessary; rare exceptions cannot be excluded.
Adrenal insufficiency and diabetes mellitus secondary to the use of topical corticosteroids for cosmetic purpose.
It is suggested that chronic use of high dose topical corticosteroid containing creams should be ruled out in patients presenting with Hypothalamo-Pituitary-Adrenal hypofunction.
Systemic effects of local treatment with high doses of potent corticosteroids in psoriatics.
The study emphasizes the risk of serious systemic effects of the absorbed corticosteroids, if high doses are used for long periods, if long periods of Corticosteroid therapy are used.
A systematic review of adverse effects associated with topical treatments for psoriasis.
Comparing the rates of adverse events associated with different topical psoriasis treatments from 1996 to March, 2002 found corticosteriods caused fewer adverse reactions compared to vitamin D analogues and tazarotene, but combination studies adverse event rates were higher than in monotherapy studies.
[The practice guideline 'atopic dermatitis'].
Since clear evidence is lacking that avoidance of exposure to inhalation or food allergens will have a favourable effect on the course of atopic dermatitis, allergological screening should be
Topical corticosteroid phobia in patients with atopic eczema
The need for provision of better information and education to patients and possibly general practitioners regarding the safety, potency and appropriate use of topical corticosteroids is highlighted.