Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis

@inproceedings{Reisman2014TopicalAO,
  title={Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis},
  author={S. Reisman and Chun-Yue I. Lee and C. Meyer and J. Proksch and S. Sonis and K. Ward},
  booktitle={Radiation research},
  year={2014}
}
Free radicals produced during cancer radiotherapy often leads to dermatitis, with the insult ranging from mild erythema to moist desquamation and ulceration. This toxicity can be dose limiting and promote chronic complications, such as fibrosis and wound recurrence. The purpose of this study was to evaluate if RTA 408, a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor nuclear factor-kappa b (NF-κB… Expand
A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice
Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers
RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity
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