Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice

  title={Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice},
  author={Bin Fan and Tao Wang and L. Bian and Z. Jian and Dongyan D. Wang and Fulun Li and Fanglong Wu and T. Bai and Gongyi Zhang and Nik Muller and Barry C. Holwerda and G. Han and Xiao-Jing Wang},
  journal={International Journal of Biological Sciences},
  pages={1163 - 1174}
The endogenous small GTPase, Rac1, plays a critical role during normal skin wound healing. It remains to be determined whether endogenous Rac1 can be appropriately activated in chronic wounds; if not, whether exogenous Rac1 has therapeutic effects on wound healing. Here we show that Rac1 protein levels were lower in wounds of db/db diabetic mice than wounds in wild type mice during the healing process. To assess the therapeutic potential of exogenous Rac1 in wound healing, we produced a Tat… Expand
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