Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.

@article{Richel2010Topical5T,
  title={Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.},
  author={Olivier Richel and Ulrike Wieland and Henry J. C. de Vries and Norbert H Brockmeyer and Cjm van Noesel and Anja Potthoff and JanM. Prins and Alexander Kreuter},
  journal={The British journal of dermatology},
  year={2010},
  volume={163 6},
  pages={
          1301-7
        }
}
BACKGROUND Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-induced potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). So far, only a few prospective studies have been performed on the topical treatment of AIN, especially at the intra-anal location. OBJECTIVES To evaluate the efficacy and safety of self-administered topical 5-fluorouracil (5-FU) treatment of AIN in HIV-positive MSM… CONTINUE READING
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