Topical α‐Tocopherol Acetate in the Bulk Phase: Eight Years of Experience in Skin Treatment

@article{Panin2004TopicalA,
  title={Topical $\alpha$‐Tocopherol Acetate in the Bulk Phase: Eight Years of Experience in Skin Treatment},
  author={Giorgio Panin and Renata Strumia and Fulvio Ursini},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1031}
}
Abstract: Clinical practice in dermatology indicates that α‐tocopherol acetate is beneficial in xerosis, hyperkeratosis, asteatotic eczema, atopic dermatitis, superficial burns, cutaneous ulcers, onychoschizia and, in general, skin diseases in which an inflammatory process is activated. The positive effect results from the combination of biological activity, the absence of adverse reactions, and the physical effect of the α‐tocopherol acetate oil. The viscosity of this oil in bulk phase… 

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References

SHOWING 1-10 OF 17 REFERENCES

The antioxidant network of the stratum corneum.

TLDR
The presented data suggest that, under conditions of environmentally challenged skin or during prooxidative dermatological treatment, topical and/or systemic application of antioxidants could support physiological mechanisms to maintain or restore a healthy skin barrier.

Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes

TLDR
Results indicate that 20 % vitamin E ointment suppresses contact dermatitis by stabilizing keratinocytes, concomitantly with novel, interesting properties.

Why don't we use vitamin E in dermatology?

  • K. PehrR. Forsey
  • Medicine
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 1993
TLDR
There was some weak or conflicting evidence that vitamin E is of value in yellow nail syndrome, vibration disease, epidermolysis bullosa, cancer prevention, claudication, cutaneous ulcers, and collagen synthesis and wound healing, but further research is needed to clarify vitamin E's role.

Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin.

TLDR
Sebaceous gland secretion is a relevant physiologic pathway for the delivery of vitamin E to upper layers of facial skin and this mechanism may serve to protect skin surface lipids and the upper stratum corneum from harmful oxidation.

Vitamin E as an in Vitro and in Vivo Antioxidant a

TLDR
The new deuterated alpha-tocopherol/GC-MS technique is providing unprecedented insight into the importance of the stereochemistry of the phytyl tail in determining bioavailability, as well as helping to discover how rapidly and effectively absorption, transport, uptake, and loss occur.

Vitamin E: protective role of a Janus molecule

  • R. RicciarelliJ. ZinggA. Azzi
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2001
TLDR
The new biochemical face of vitamin E was first described in 1991, with an inhibitory effect on cell proliferation and protein kinase C activity, and its nonantioxidant role is well established, as confirmed by authoritative studies of signal transduction and gene regulation.

Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries

TLDR
This research sought to identify inexpensive, safe, vegetable oils available in developing countries that improved epidermal barrier function and saw adverse ultrastructural changes seen under transmission electron microscopy in keratin intermediate filament, mitochondrial, nuclear, and nuclear envelope structure following a single application of mustard oil.

Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

TLDR
An overview of the antioxidant system with a special relevance to skin is provided, which has been identified as the predominant antioxidant both in murine and human skin and shows a characteristic gradient with lower levels towards the outer stratum corneum layers.