Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H).

@article{Alshryda2013TopicalT,
  title={Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H).},
  author={S Alshryda and James S Mason and Praveen Sarda and Antoni Viraf Francis Nargol and Nick J Cooke and Hafeez Ahmad and S Tang and Raj Logishetty and Manesh Vaghela and Lynne McPartlin and Amritpal S Hungin},
  journal={The Journal of bone and joint surgery. American volume},
  year={2013},
  volume={95 21},
  pages={1969-74}
}
BACKGROUND Approximately one-third of patients undergoing total hip replacement surgery require one to three units of blood postoperatively. Tranexamic acid is a synthetic antifibrinolytic agent that has been successfully used intravenously to control bleeding after total hip replacement. A topical application is easy to administer, provides a maximum concentration of tranexamic acid at the bleeding site, and is associated with little or no systemic absorption of the tranexamic acid. METHODS… CONTINUE READING
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