Top-down modulation of prepulse inhibition of the startle reflex in humans and rats.

@article{Li2009TopdownMO,
  title={Top-down modulation of prepulse inhibition of the startle reflex in humans and rats.},
  author={Liang Li and Yi Du and Nanxin Li and Xihong Wu and Yanhong Wu},
  journal={Neuroscience and biobehavioral reviews},
  year={2009},
  volume={33 8},
  pages={1157-67}
}
Prepulse inhibition (PPI) is the attenuation of the startle reflex when the sudden intense startling stimulus is shortly preceded by a weaker, non-startling sensory stimulus (prepulse). PPI reflects a protective function of reducing disruptive influences to the processing of prepulse signals and is recognized as a model of sensorimotor gating. In humans, PPI is modulated by both attentional and emotional responses to prepulse, indicating that this early-stage gating is top-down modulated by… CONTINUE READING