Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra.

  title={Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra.},
  author={D. Schwudke and J. T. Hannich and V. Surendranath and Vinciane Grimard and T. Moehring and Lyle Burton and T. Kurzchalia and A. Shevchenko},
  journal={Analytical chemistry},
  volume={79 11},
  • D. Schwudke, J. T. Hannich, +5 authors A. Shevchenko
  • Published 2007
  • Chemistry, Medicine
  • Analytical chemistry
  • Direct profiling of total lipid extracts on a hybrid LTQ Orbitrap mass spectrometer by high-resolution survey spectra clusters species of 11 major lipid classes into 7 groups, which are distinguished by their sum compositions and could be identified by accurately determined masses. Rapid acquisition of survey spectra was employed as a "top-down" screening tool that, together with the computational method of principal component analysis, revealed pronounced perturbations in the abundance of… CONTINUE READING
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